Metabolic reprograming in macrophage polarization.
Citation:
Galván-Peña S, O'Neill LA, Metabolic reprograming in macrophage polarization., Frontiers in immunology, 5, 2014, 420Download Item:
Abstract:
Studying the metabolism of immune cells in recent years has emphasized the tight link
existing between the metabolic state and the phenotype of these cells. Macrophages in
particular are a good example of this phenomenon. Whether the macrophage obtains its
energy through glycolysis or through oxidative metabolism can give rise to different pheno-
types. Classically activated or M1 macrophages are key players of the first line of defense
against bacterial infections and are known to obtain energy through glycolysis. Alterna-
tively activated or M2 macrophages on the other hand are involved in tissue repair and
wound healing and use oxidative metabolism to fuel their longer-term functions. Metabolic
intermediates, however, are not just a source of energy but can be directly implicated in
a particular macrophage phenotype. In M1 macrophages, the Krebs cycle intermediate
succinate regulates HIF1
a
, which is responsible for driving the sustained production of
the pro-inflammatory cytokine IL1
b
. In M2 macrophages, the sedoheptulose kinase car-
bohydrate kinase-like protein is critical for regulating the pentose phosphate pathway. The
potential to target these events and impact on disease is an exciting prospect
Author's Homepage:
http://people.tcd.ie/laoneillDescription:
PUBLISHED
Author: O'NEILL, LUKE
Type of material:
Journal ArticleCollections
Series/Report no:
Frontiers in immunology5
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Full text availableKeywords:
metabolism, macrophage, HIF, glycolysisDOI:
http://dx.doi10.3389/fimmu.2014.00420Metadata
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