Browsing Clinical Medicine by Title
Now showing items 642-661 of 948
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Obesity, insulin resistance and Type 2 Diabetes in young Irish people
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The epidemic of obesity in Irish youth, one of the highest ranking internationally, represents a major threat to public health. However, little is known of the metabolic and clinical characteristics of this cohort. I ... -
Ocular Microtremor as a clinical and scientific tool in neurologic disease : validation and application of a generalised discovery protocol
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Ocular microtremor (OMT) , a high frequency low amplitude eye movement, is one of three fixational eye movements present even when the eyes are apparently at rest. The tremor is thought to be related to tonic neural ... -
Ocular microtremor measurement, characterization & analysis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Ocular Microtremor (OMT) is a high frequency tremor of the eye present in all normal subjects even if the eye is apparently still. It is one of the fixational eye movements. Changes in the OMT frequency and pattern have ... -
Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children
(Oxford University Press, 2016)Background: Individuals infected with Mycobacterium tuberculosis (Mtb) may develop symptoms and signs of disease (tuberculosis disease) or may have no clinical evidence of disease (latent tuberculosis infection [LTBI]). ... -
Old King Coal - molecular mechanisms underlying an ancient treatment for atopic eczema.
(2013)Traditional remedies for common disorders have been known for centuries, but insight into their mechanism of action is often limited. In this issue of the JCI, Joost Schalkwijk’s research group at the Radboud University ... -
On dignity in inpatient psychiatric care
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Dignity is an important concept in human rights legislation and medical ethics but is under-studied in psychiatric settings. It is a nuanced concept which is considered difficult to define, but nevertheless has a prominent ... -
On the Genotype and Phenotype of inherited retinal degenerations in an irish popultion
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Aim: To elucidate the molecular diagnosis and perform deep phenotyping on patients with inherited retinal degenerations (IRDs) Methods: Patients were identified through self-referral or referral by an ophthalmologist ... -
Optimal use of immunomodulator and biological therapy in Inflammatory Bowel Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Loss of response (LOR) to anti-TNFa therapy is a significant problem, and leads to increased hospitalisation rates, surgical intervention, and steroid dependency. Loss of response is multifactorial. However there ... -
Optimally tolerated dose of lapatinib in combinationwith docetaxel plus trastuzumab in first-line treatmentof HER2-positive metastatic breast cancer
(2013)Background: This phase IB, open-label, dose-escalation study evaluated the safety, tolerability, and optimally tolerated regimen (OTR) of lapatinib in combination with docetaxel and trastuzumab in patients with ... -
Optimising the In-Hospital Management of Hip Fracture Using the Irish Hip Fracture Database
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Hip fracture can have a devastating impact on older adults as it is associated with reduced life expectancy, loss of independence and poorer quality of life. Each year in Ireland approximately 3,600 patients experience a ... -
Oral levosimendan in amyotrophic lateral sclerosis: A phase II multicentre, randomised, double-blind, placebo-controlled trial
(2019)Objective: To evaluate the efficacy and safety of oral levosimendan in patients with amyotrophic lateral sclerosis (ALS). This phase II, randomised, double-blind, placebo-controlled, crossover, three-period study with 6 ... -
Oral symptom assessment tools in patients with advanced cancer: a scoping review
(2022)Purpose: Oral symptoms are common in patients with advanced cancer. The aim of this scoping review was to identify oral symptom assessment tools that have been specifically utilised in patients with "advanced cancer". Methods: ... -
Orthostatic Hypotension as a marker of Frailty in Older People
(Trinity College Dublin, School of Medicine, Department of Medical Gerontology, 2011)This doctoral investigation endeavoured to explore the association between orthostatic hypotension (OH) and frailty in community-dwelling older people, in order to assess the validity of to-date untested, clinically grounded ... -
Osteoporosis in adults with axial spondyloarthritis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Osteoporosis was the most prevalent comorbidity in individuals with axial spondyloarthropathy (axSpA) in a large multinational study. Ireland was not included in that study, so it was unknown if the profile of comorbidities ... -
Overweight and obesity among older adults upon admission to hospital
(2011)Poor nutritional status, which includes both under- and over-nutrition, is associated with poor health outcomes. This cross-sectional study assessed the nutritional status of older patients admitted to an acute geriatric ... -
P-glycoprotein expression and function, relationship to plasma and intracellular drug concentrations, and the effects of HIV disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)P-glycoprotein Expression and Function: Peripheral blood lymphocytes (PBMCs) were isolated by Ficoll density gradient centrifugation, fixed and permeabilised. P- glycoprotein (P-gp) expression was quantified by flow cytometry ... -
Palliative care in amyotrophic lateral sclerosis: a review of current international guidelines and initiatives
(BMJ, 2011)Background: Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative condition. Optimal management requires a palliative approach from diagnosis with emphasis on patient autonomy, dignity and ... -
Palliative care in the era of novel oncological interventions: needs some "tweaking"
(2022)Cancer treatment has evolved enormously over the last 20 years, with developments in surgery, radiotherapy, chemo- therapy, targeted therapy, and immunotherapy. As a result, many cancer patients have improved outcomes ...