P-glycoprotein expression and function, relationship to plasma and intracellular drug concentrations, and the effects of HIV disease
Citation:
Martina Joan Hennessy, 'P-glycoprotein expression and function, relationship to plasma and intracellular drug concentrations, and the effects of HIV disease', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007, pp 183Abstract:
P-glycoprotein Expression and Function: Peripheral blood lymphocytes (PBMCs) were isolated by Ficoll density gradient centrifugation, fixed and permeabilised. P- glycoprotein (P-gp) expression was quantified by flow cytometry following staining with a P-gp specific antibody (JSBl). Vimentin and IE (nonsense antibody) were used as controls. The presence of the MDR 1 gene product was confirmed by RT-PCR. A rhodamine efflux assay was used to assess P-gp function.
Author: Hennessy, Martina Joan
Advisor:
Barry, MichaelQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical MedicineNote:
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