Browsing Clinical Medicine by Date of Publication
Now showing items 1-20 of 927
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Deriving a useful packed cell volume estimate from haemoglobin analysis
(1994)A method is described whereby the packed cell volume (PCV) of a blood sample can be estimated from the haemoglobin concentration. The method defines the relation existing between haemoglobin concentration and the PCV of ... -
Alterations in cytochrome-c oxidase expression between praziquantel-resistant and susceptible strains of Schistosoma mansoni.
(1998)The genetic differences between praziquantel-resistant (R) and susceptible (S) strains of Schistosoma mansoni (Fallon & Doenhoff, 1994) were explored using RAPD and by cloning differentially expressed mRNAs by subtractive ... -
The "thermolabile" variant of methylenetetrahydrofolate reductase and neural tube defects: An evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother
(1999)Recent reports have implicated the "thermolabile" (T) variant of methylenetetrahydrofolate reductase (MTHFR) in the causation of folate-dependent neural tube defects (NTDs). We report herein the largest genetic study of ... -
Simultaneous disruption of Interleukin (IL)-4 and IL-13 defines individual roles in T Helper cell Type 2-mediated responses
(The Rockefeller University Press, 1999)Using a single vector targeting strategy, we have generated mice with a combined deficiency of interleukin (IL)-4 and IL-13 to clarify their roles in T helper type 2 (Th2) cell responses. Using immunological challenges ... -
Homocysteine, folate enzymes and neural tube defects
(1999)Background: The purpose of this study was to characterize total homocysteine (tHcy) levels at birth in preterm and term infants and identify associations with intraventricular hemorrhage (IVH) and other neonatal outcomes ... -
Nutritional aspects of trans unsaturated fatty acids
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Dietary trans unsaturated fatty acids from hydrogenated vegetable and fish oils have been shown to raise plasma low density lipoprotein cholesterol and lower high density lipoprotein cholesterol levels at 10%, 6% and 3% ... -
Tools and techniques for improving the assessment of exposure to food chemicals
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Exposure assessments are an integral part of risk assessment and are essential for protecting consumer health and factilitating international trade. The aim of this thesis was to explore the potential usefulness of a number ... -
Virulent Mycobacterium tuberculosis Strains Evade Apoptosis of Infected Alveolar Macrophages
(2000)Human alveolar macrophages (AMφ) undergo apoptosis following infection with Mycobacterium tuberculosis in vitro. Apoptosis of cells infected with intracellular pathogens may benefit the host by eliminating a supportive ... -
The nutritional status of hospital patients and healthy elderly living in the community
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Protein-energy undernutrition is known to occur in patients on admission to hospital. In a prospective study of 594 sequential hospital admissions, we assessed the prevalence of undernutrition among patients on admission ... -
Nutritional and metabolic aspects of n-3 polyunsaturated fatty acids in health and disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)The health benefits of fish oils, rich in the n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are multi-faceted, spanning a number of human systems, including the cardiovascular, ... -
Particulate air pollution and mortality in Dublin 1980-1996
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Air pollution in Dublin was studied for the period from 1980 to 1996. The factors which contribute to air pollution were investigated, and the nature of particulate air pollution is discussed. The trends in air pollution, ... -
A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma
(Nature, 2001)The incidence of oesophageal adenocarcinoma is rising; to date, no susceptibility genes have been identified. p73, a novel p53 homologue, maps to chromosome 1p36, a region commonly deleted in oesophageal cancers. p73 shares ... -
Methodological issues in risk assessment of human exposure to artificial sweeteners in food
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The primary aim of this thesis is in estimating food chemical intakes with a specific interest in the area of intense sweeteners. To date all studies of intense sweeteners have been extremely detailed both in the estimate ... -
The study of periodicity of eating & public health nutrition issues
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)This thesis set out to provide an objective understanding of periodicity of eating in a group of free- living adults, by determining the temporal pattern of nutrient intake during eating occasions throughout the day. A ... -
Evaluation of Triple helix-forming Oligonucleotides as modulators of transcriptional initiation in erbB-2/HER-2-positive breast cancer : an anti-tumour approach
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)Research over the last several decades has made tremendous strides in the identification of the components of the human genome. Genetic information is expressed by translation of DNA into functional proteins through the ... -
Dietary and genetic factors affecting the cholesteryl ester transfer protein and lipoprotein metabolism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The cholesteryl ester transfer protein (CETP) plays an inherent role in the redistribution of neutral lipids between high density lipoproteins (HDL) and very low density lipoproteins (VLDL) and low density lipoproteins ... -
The folate catabolic process, its implications for folate requirement in humans and its antibacterial drug function
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The one-carbon cycle, of which folate is the predominant constituent, is a major carrier of one-carbon units for biochemical synthesis, and is thought to be the sole mechanism of methyl-group transfer. It is involved both ... -
Postprandial lipoprotein metabolism in diabetes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)Cardiovascular disease is up to four times greater in patients with Type 2 diabetes compared with nonnoglycaemic individuals (Pyorala et al., 1987; Laakso and Lehto 1997). Abnormalities in lipid metabolism may, in part, ...