Browsing Clinical Medicine by Title
Now showing items 251-270 of 947
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E-health empowers patients with ulcerative colitis: a randomised controlled trial of the web-guided 'Constant-care' approach.
(2010)Background: The natural history of ulcerative colitis requires continuous monitoring of medical treatment via frequent outpatient visits. The European health authorities' focus on e-health is increasing. Lack of easy access ... -
Early Immune Responses to Emerging and Enduring Respiratory Pathogens
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)For most of recent history, Tuberculosis (TB) has been the leading cause of death by an infective agent worldwide. Tuberculosis is caused by Mycobacterium tuberculosis (Mtb), which infects human lungs following respiratory ... -
Early Satiety in Cancer: An Investigation into a Highly Impactful Orphan Symptom
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Patients with cancer experience multiple symptoms throughout the different stages of cancer care. One common symptom related to nutritional intake is known as early satiety. This symptom has no agreed definition but has ... -
Ebola outbreak response; experience and development of screening tools for viral haemorrhagic fever (VHF) in a HIV center of excellence near to VHF epicentres.
(2014)There have been 3 outbreaks of viral hemorrhagic fever (VHF) in Uganda in the last 2 years. VHF often starts with non-specific symptoms prior to the onset of haemorrhagic signs. HIV clinics in VHF outbreak countries such ... -
ECAS A-B-C: alternate forms of the Edinburgh Cognitive and Behavioural ALS Screen
(2018)Background: The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) is a short assessment by which neuropsychological symptoms can be detected and quantified in people with ALS. To avoid potential practice effects with ... -
Editorial: IL-1 Family Members in Health and Disease
(2019)In 1985, two distinct cDNAs encoding proteins sharing human Interleukin-1 (IL-1) activity were described, thus defining the first two members of the IL-1 family—IL-1α and IL-1β. These potent pro-inflammatory cytokines have ... -
Editorial: Tregs and BCG - Dangerous liaisons in TB
(2010)A discussion on paper by Ho et al. providing evidence to support the hypothesis that Treg cells induced by environmental mycobacteria do indeed constrain immunity induced by BCG. -
Efavirenz- but not nevirapine-based antiretroviral therapy decreases exposure to the levonorgestrel released from a sub-dermal contraceptive implant.
(2014)INTRODUCTION: Sub-dermal hormone implants, such as levonorgestrel (LNG), are a safe and desirable form of long-acting contraception, but their use among HIV-positive women on antiretroviral therapy (ART) may be compromised ... -
Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults.
(2007)Background: Mandatory folic acid fortification of food is effective in reducing neural tube defects and may even reduce stroke-related mortality, but it remains controversial because of concerns about potential adverse ... -
Effect of Area-Level Socioeconomic Deprivation on Risk of Cognitive Dysfunction in Older Adults.
(2018)OBJECTIVES: To investigate the relationship between area‐level deprivation and risk of cognitive dysfunction. DESIGN: Cross‐sectional analysis. SETTING: The Trinity, Ulster, and Department of Agriculture (TUDA) ... -
Effect of BRCA Mutations on Metastatic Relapse and Cause-specific Survival After Radical Treatment for Localised Prostate Cancer
(2015)Background: Germline BRCA mutations are associated with worse prostate cancer (PCa) outcomes; however, the most appropriate management for mutation carriers has not yet been investigated. Objective: To evaluate the ... -
The effect of sleeping with the head of the bed elevated six inches on elderly patients with orthostatic hypotension: an open randomised controlled trial.
(2011)the evidence for 6-inch tilt sleeping-head-up (SHU), a common therapy for the treatment of orthostatic hypotension (OH) in older people, is unavailable.; to investigate the effects of 6-inch SHU for 6 weeks in community-living ... -
The Effect of Tuberculosis Antimicrobials on the Immunometabolic Profiles of Primary Human Macrophages Stimulated with Mycobacterium tuberculosis
(2021)Tuberculosis (TB) remains a global health challenge. Patients with drug-sensitive and drug-resistant TB undergo long, arduous, and complex treatment regimens, often involving multiple antimicrobials. While these drugs were ... -
The effects of a home-based arm ergometry exercise programme on physical fitness, fatigue and activity in polio survivors: Protocol for a randomised controlled trial
(2012)Many Polio survivors have reduced mobility, pain and fatigue, which make access to conventional forms of aerobic exercise difficult. Inactivity leads to increased risk of health problems, many of which are prevalent among ... -
Effects of bile acids and fatty acids on cell signalling in human colorectal cancer cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Colorectal cancer is a multifactorial disease. The interplay between genetic and environmental factors leads to the development of CRC. There have been great advancements in the knowledge of genetic alterations leading to ... -
Effects of polyunsaturated fatty acids on mediators of inflammation associated with atherosclerosis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)The inflammatory pathogenesis of atherosclerosis has been defined, largely by the “response to injury” hypothesis. The morphological development of atherosclerosis has also been defined. Monocytes and lymphocytes accumulate ... -
Effects of prenatal fish-oil and 5-methyltetrahydrofolate supplementation on cognitive development of children at 6.5 y of age.
(2011)Background: The influence of prenatal long-chain polyunsaturated fatty acids (LC-PUFAs) and folate on neurologic development re- mains controversial. Objective: The objective was to assess the long-term effects of ... -
Efficacy and Safety of Belimumab and Azathioprine for Maintenance of Remission in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Randomized Controlled Study
(2019)Objective: To evaluate the safety and efficacy of belimumab as adjunctive therapy to maintain remission in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). Methods: In this multicenter, ... -
Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug delivery
(2015)Introduction Tumor cells can effectively be killed by heat, e.g. by using magnetic hyperthermia. The main challenge in the field, however, is the generation of therapeutic temperatures selectively in the whole tumor ...
