Effects of prenatal fish-oil and 5-methyltetrahydrofolate supplementation on cognitive development of children at 6.5 y of age.
Citation:
Campoy C, Escolano-Margarit MV, Ramos R, Parrilla-Roure M, Csábi G, Beyer J, Ramirez-Tortosa MC, Molloy AM, Decsi T, Koletzko BV, Effects of prenatal fish-oil and 5-methyltetrahydrofolate supplementation on cognitive development of children at 6.5 y of age., The American journal of clinical nutrition, 94, 6 Suppl, 2011, 1880S-1888SDownload Item:
Abstract:
Background:
The influence of prenatal long-chain polyunsaturated
fatty acids (LC-PUFAs) and folate on neurologic development re-
mains controversial.
Objective:
The objective was to assess the long-term effects of n
2
3
(omega-3) LC-PUFA supplementatio
n, 5-methyltetrahydrofolate
(5-MTHF) supplementation, or both in pregnant women on cogni-
tive development of offspring at 6.5 y of age.
Design:
This was a follow-up study of the NUHEAL (Nutraceuticals
for a Healthier Life) cohort. Healthy pregnant women in 3 European
centers were randomly assigned to
4 intervention groups. From the
20th week of pregnancy until delivery, they received a daily supplement
of 500 mg docosahexaenoic acid (DHA) + 150 mg eicosapentaenoic
acid [fish oil (FO)], 400
l
g 5-MTHF, or both or a placebo. Infants
received formula containing 0.5% DHA and 0.4% arachidonic acid
(AA) if they were born to mothers r
eceiving FO supplements or were
virtually free of DHA and AA until the age of 6 mo if they belonged to
the groups that were not supplement
ed with FO. Fatty acids and folate
concentrations were determined
in maternal blood at weeks 20 and 30
of pregnancy, at delivery, and in cord blood. Cognitive function was
assessed at 6.5 y of age with the K
aufman Assessment Battery for
Children (K-ABC).
Results:
We observed no significant differences in K-ABC scores
between intervention groups. Higher DHA in maternal erythrocytes
at delivery was associated with a Mental Processing Composite
Score higher than the 50th percentile in the offspring.
Conclusion:
We observed no significant effect of supplementation
on the cognitive function of children, but maternal DHA status may
be related to later cognitive function in children. This trial was
registered at clinicaltrials.gov as NCT01180933.
Am J Clin
Nutr
2011;94(suppl):1880S–8S
Author's Homepage:
http://people.tcd.ie/amolloyDescription:
PUBLISHED
Author: MOLLOY, ANNE
Type of material:
Journal ArticleCollections
Series/Report no:
The American journal of clinical nutrition94
6 Suppl
Availability:
Full text availableKeywords:
neurologic developmentSubject (TCD):
International DevelopmentDOI:
http://dx.doi.org/10.3945/ajcn.110.001107ISSN:
0002-9165Metadata
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