Editorial: IL-1 Family Members in Health and Disease
Citation:
Brint, E. and Kamradt, T. and Doyle, S.L., Editorial: IL-1 Family Members in Health and Disease, Frontiers in Immunology, 10, 2596, 2019Download Item:
fimmu-10-02596.pdf (PDF) 152.2Kb
Abstract:
In 1985, two distinct cDNAs encoding proteins sharing human Interleukin-1 (IL-1) activity were described, thus defining the first two members of the IL-1 family—IL-1α and IL-1β. These potent pro-inflammatory cytokines have been the subject of much research in the area of fever and inflammation, as well as for their roles in a myriad of inflammatory associated diseases. Over the years the family expanded to include cytokines with both pro- and anti- inflammatory properties, including IL-18, IL-33, IL-36, IL-37, IL-38, IL-1 receptor antagonist (IL-1Ra), and IL-36Ra. In addition to the 11 identified cytokine members of this family, there are now multiple discrete receptor family members, that form 4 functional receptor complexes able to activate downstream signaling cascades, as well as several decoy and inhibitory receptors.
URI:
https://www.frontiersin.org/articles/10.3389/fimmu.2019.02596/fullhttp://hdl.handle.net/2262/91155
Sponsor
Grant Number
Science Foundation Ireland (SFI)
SFI/18/TIDA/6067
Science Foundation Ireland (SFI)
SFI/15/CDA/3497
Author's Homepage:
http://people.tcd.ie/doyles8Description:
PUBLISHEDcited By 0
Author: Doyle, Sarah
Type of material:
Journal ArticleURI:
https://www.frontiersin.org/articles/10.3389/fimmu.2019.02596/fullhttp://hdl.handle.net/2262/91155
Collections:
Series/Report no:
Frontiers in Immunology10
2596
Availability:
Full text availableKeywords:
cDNAs encoding proteins, Inflammation, Disease, Interleukin, IL-1, IL-18, IL-33DOI:
http://dx.doi.org/10.3389/fimmu.2019.02596Licences: