Browsing Clinical Medicine by Title
Now showing items 757-776 of 949
-
Respiratory measures in amyotrophic lateral sclerosis
(2018)Objective: Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease that causes skeletal muscle weakness, including muscles involved with respiration. Death often results from respiratory failure within ... -
Response: Disseminated tuberculosis.
(Oxford University Press, 2017)Lymphopaenia is described among patients with tuberculosis.The lymphocyte count for the patient in our publication prior to treatment was 0.8 (1–2 1016ml). At the time of writing, he is still receiving his anti-tuberculous ... -
Resting-state electroencephalographic biomarkers for tracking cognitive network dysfunction in amyotrophiclateral sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Amyotrophic lateral sclerosis (ALS) stands as a multifaceted neurological disorder that primarily affects both upper and lower motor neurons. However, research in neuroimaging, neuropsychology and neurobiology has shown ... -
Retrospective analysis of attitudes to ageing in the Economist: apocalyptic demography for opinion formers.
(2009)Objective To investigate the description of older people and ageing in a major weekly newspaper, influential in political and financial circles, to see whether it reflected ageing in a balanced manner, and to what extent ... -
Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism.
(2006)Background? Meta-analyses predict that a 25% lowering of plasma homocysteine would reduce the risk of coronary heart disease by 11% to 16% and stroke by 19% to 24%. Individuals homozygous for the methylenetetrahydrofolate ... -
Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine
(2014)Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase red uctase (MTRR), riboflavin- dependent enzymes, participat e in homocysteine metabolism. Reported effects of riboflavin status on the ... -
Risk management framework for nano-biomaterials used in medical devices and advanced therapy medicinal products
(2020)The convergence of nanotechnology and biotechnology has led to substantial advancements in nano-biomaterials (NBMs) used in medical devices (MD) and advanced therapy medicinal products (ATMP). However, there are concerns ... -
A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.
(2013)Type 2 innate lymphoid cells (ILC2s, nuocytes, NHC) require RORA and GATA3 for their development. We show that human ILC2s express skin homing receptors and infiltrate the skin after allergen challenge, where they produce ... -
A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins.
(2011)Clostridium difficile is the etiological agent of antibiotic-associated diarrhoea (AAD) and pseudomembranous colitis in humans. The role of the surface layer proteins (SLPs) in this disease has not yet been fully explored. ... -
The role of angiopoietins and their mediators in symptomatic small bowel angiodysplasia; identifying novel diagnostic and therapeutic targets in chronic anaemia and obscure gastrointestinal bleeding
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Title : The role of angiopoietins and their mediators in symptomatic small bowel angiodysplasia; identifying novel diagnostic and therapeutic targets in chronic anaemia and obscure gastrointestinal bleeding. Author: Dr ... -
The role of canonical and non-canonical inflammasomes in a model of oxidative stress-induced retinal degeneration
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Retinal degenerative diseases like age-related macular degeneration (AMD) are a leading cause of visual impairment. Oxidative stress is known to be important in the pathogenesis of AMD, and oxidative-stress induced retinal ... -
The role of chemokines in acute and chronic hepatitis C infection.
(2014)Hepatitis C imposes a significant burden on global healthcare. Chronic infection is associated with progressive inflammation of the liver which typically manifests in cirrhosis, organ failure and cancer. By virtue of ... -
?The role of energy metabolism in driving disease progression in inflammatory, hypoxic and angiogenic microenvironments'.
(2015)Cellular metabolism plays a crucial role in primed inflammatory, hypoxic and angiogenic microenvironments by supporting disease progression in a range of disease entities. To adapt to fluctuating stress-induced ... -
The role of epigenetics in resistance to cisplatin chemotherapy in lung cancer
(2011)Non-small cell lung cancer (NSCLC) is the most common cause of cancer related death in the world. Cisplatin and carboplatin are the most commonly used cytotoxic chemotherapeutic agents to treat the disease. These agents, ... -
The Role of Epigenetics in Resistance to Cisplatin Chemotherapy in Lung Cancer
(2011)Non-small cell lung cancer (NSCLC) is the most common cause of cancer related death in the world. Cisplatin and carboplatin are the most commonly used cytotoxic chemotherapeutic agents to treat the disease. These agents, ... -
The Role of EUS and Proteomic Analysis in the Management and Surveillance of Pancreatic Cystic Lesions
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction Pancreatic cystic lesions (PCL) can be precursors to pancreatic cancer. The incidence of PCL are increasing worldwide with increased patient age and reliance on cross sectional imaging. However, not all PCL ... -
The role of monocytes in ANCA associated vascultis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)ANCA associated vasculitis (AAV) encompasses several autoimmune conditions characterised by destruction of small vessels, inflammation of the respiratory tract, and glomerulonephritis. Most patients harbour autoantibodies ... -
Role of Notch signaling in regulating innate immunity and inflammation in health and disease
(2016)The Notch signaling pathway is conserved from Droso- phila to mammals and is critically involved in develop- mental processes. In the immune system, it has been established that Notch signaling regulates multiple steps ...