?The role of energy metabolism in driving disease progression in inflammatory, hypoxic and angiogenic microenvironments'.
Citation:
Phelan JJ, O?Hanlon C, Reynolds JV, O?Sullivan J., ?The role of energy metabolism in driving disease progression in inflammatory, hypoxic and angiogenic microenvironments'., Gastro Open Journal, 1, 2, 2015, 44-58Download Item:
Abstract:
Cellular metabolism plays a crucial role in primed inflammatory, hypoxic and angiogenic
microenvironments by supporting disease progression in a range of disease entities.
To adapt to fluctuating stress-induced microenvironments, pre-neoplastic and neoplastic tissue
must utilise a diverse range of molecular mediators to alter their metabolism. Despite being
widely documented to play independent roles in disease prevalence, these complex processes
exploit a range of key cellular components that act in tandem to restore metabolic equilibrium.
Therefore, this review examines the primary molecular mechanisms linking energy metabolism
with inflammation, hypoxia and angiogenesis. Furthermore, the review considers a diverse
range of conventional and novel mediators that link energy metabolism and hypoxia. Moreover,
to investigate their reciprocal relationship and the mechanisms employed to execute their
functional effect in greater detail, the roles of glycolysis and oxidative phosphorylation in rheumatoid
arthritis and circadian rhythms respectively are reviewed. Lastly, this review explores
some current metabolic-based treatments and multi-targeted therapies that could potentially
target these fundamental cellular processes.
URI:
https://openventio.org/the-role-of-energy-metabolism-in-driving-disease-progression-in-inflammatory-hypoxic-and-angiogenic-microenvironments/http://hdl.handle.net/2262/90702
Author's Homepage:
http://people.tcd.ie/phelanj3Description:
PUBLISHED
Author: Phelan, James
Type of material:
Journal ArticleURI:
https://openventio.org/the-role-of-energy-metabolism-in-driving-disease-progression-in-inflammatory-hypoxic-and-angiogenic-microenvironments/http://hdl.handle.net/2262/90702
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Series/Report no:
Gastro Open Journal1
2
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Full text availableKeywords:
Energy metabolism, Inflammation, Hypoxia, AngiogenesisSubject (TCD):
CancerDOI:
http://dx.doi.org/10.17140/GOJ-1-108Licences: