miR-19a: An Effective Regulator of SOCS3 and Enhancer of JAK-STAT Signalling.
Item Type:Journal Article
Citation:Collins AS, McCoy CE, Lloyd AT, O'Farrelly C, Stevenson NJ, miR-19a: An Effective Regulator of SOCS3 and Enhancer of JAK-STAT Signalling., PloS one, 8, 7, 2013, e69090
journal.pone.0069090.pdf (PDF) 549.3Kb
Bioinformatic analysis identified highly conserved 3’UTR miR-19a target sequences in several JAK-STAT associated genes, including SOCS1, SOCS3, SOCS5 and Cullin (Cul) 5. Functional studies revealed that miR-19a significantly decreased SOCS3 mRNA and protein, while a miR-19a antagomir specifically reversed its inhibitory effect. Furthermore, miR-19a-mediated reduction of SOCS3 enhanced IFN-α and interleukin (IL)-6 signal transduction through STAT3. These results reveal a novel mechanism by which miR-19a may augment JAK-STAT signal transduction via control of SOCS3 expression and are fundamental to the understanding of inflammatory regulation.
Author: O'FARRELLY, CLIONA
Type of material:Journal Article
Series/Report no:PloS one
Availability:Full text available
Keywords:3’UTR, Cytokines, DNA-binding proteins, Gene expression, Gene targeting, MicroRNAs, STAT proteins
Subject (TCD):Immunology, Inflammation & Infection