Poxviral protein A46 antagonizes Toll-like receptor 4 signaling by targeting BB loop motifs in Toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactions.
Citation:
Stack J, Bowie AG, Poxviral protein A46 antagonizes Toll-like receptor 4 signaling by targeting BB loop motifs in Toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactions., The Journal of biological chemistry, 287, 27, 2012, 22672-22682Download Item:
Abstract:
TLR4 signaling is inhibited by
poxviral protein A46, but the mechanism is
unknown.
Results: We identify the protein interaction
surfaces within the TLR4 complex that A46
antagonises, and characterize the interaction
between A46 and TRAM.
Conclusion: A46 prevents receptor:adaptor
interactions, and has a TRAM-specific
interaction motif.
Significance: This work reveals the molecular
basis for poxviral antagonism of TLR4
Sponsor
Grant Number
Science Foundation Ireland (SFI)
07/SRC/B1144
Author's Homepage:
http://people.tcd.ie/agbowieDescription:
PUBLISHED
Author: BOWIE, ANDREW
Type of material:
Journal ArticleCollections
Series/Report no:
The Journal of biological chemistry287
27
Availability:
Full text availableKeywords:
Toll-like receptors (TLRs)Subject (TCD):
Immunology, Inflammation & InfectionDOI:
http://dx.doi.org/10.1074/jbc.M112.349225ISSN:
0021-9258Metadata
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