Removing the TREX1 safety net: oxidized DNA overcomes immune silencing by exonuclease TREX1.
Item Type:Journal Article
Citation:Bowie AG, Removing the TREX1 safety net: oxidized DNA overcomes immune silencing by exonuclease TREX1., Immunity, 39, 3, 2013, 423-5
Bowie oxDNA Imm Prev author version.pdf (Published (author's copy) - Peer Reviewed) 669.0Kb
If DNA accumulates in the cytosol it activates innate immunity via recently described DNA sensors. In this issue of Immunity Gehrke et al. (2013) show that oxidized DNA is resistant to degradation by TREX1 and thus has heightened immune stimulatory capacity.
PubMed ID: 24054323
Author: BOWIE, ANDREW
Type of material:Journal Article
Availability:Full text available
Subject (TCD):Immunology, Inflammation & Infection