Removing the TREX1 safety net: oxidized DNA overcomes immune silencing by exonuclease TREX1.
Citation:
Bowie AG, Removing the TREX1 safety net: oxidized DNA overcomes immune silencing by exonuclease TREX1., Immunity, 39, 3, 2013, 423-5Download Item:
Abstract:
If DNA accumulates in the cytosol it activates innate immunity via recently
described DNA sensors. In this issue of Immunity Gehrke et al. (2013) show that
oxidized DNA is resistant to degradation by TREX1 and thus has heightened
immune stimulatory capacity.
Author's Homepage:
http://people.tcd.ie/agbowieDescription:
PUBLISHEDPubMed ID: 24054323
Author: BOWIE, ANDREW
Type of material:
Journal ArticleCollections
Series/Report no:
Immunity39
3
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Full text availableKeywords:
DNASubject (TCD):
Immunology, Inflammation & InfectionDOI:
http://dx.doi.org/10.1016/j.immuni.2013.08.023ISSN:
1074-7613Metadata
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