The role of non-degradative ubiquitination in interleukin-1 and Toll-like receptor signalling.
Item Type:Journal Article
Citation:Keating, SE, Bowie, AG, The role of non-degradative ubiquitination in interleukin-1 and Toll-like receptor signalling., The Journal of Biological Chemistry, 284, 13, 2009, 8211 - 8215
Keating Uq minireivew JBC author version.pdf (Published (author's copy) - Peer Reviewed) 276.6Kb
The induction of an appropriate immune response upon infection of an invading pathogen is controlled by host pattern recognition receptors (PRRs)* that specifically recognise essential structural components of infectious agents termed pathogen-associated molecular patterns (PAMPs) (1-3). Detection of PAMPs by PRRs triggers intracellular signalling pathways leading to the expression of immune mediators such as cytokines, chemokines and type I interferons (IFNs). Toll-like receptors (TLRs) represent a now well-defined PRR family, since much has been discovered recently in terms of the PAMPs they interact with, the downstream signalling pathways triggered and the complex yet specific immune responses elicited.
Author: BOWIE, ANDREW
Type of material:Journal Article
Series/Report no:The Journal of Biological Chemistry
Availability:Full text available
Subject (TCD):Immunology, Inflammation & Infection