The role of non-degradative ubiquitination in interleukin-1 and Toll-like receptor signalling.
Citation:
Keating, SE, Bowie, AG, The role of non-degradative ubiquitination in interleukin-1 and Toll-like receptor signalling., The Journal of Biological Chemistry, 284, 13, 2009, 8211 - 8215Download Item:
Abstract:
The induction of an appropriate
immune response upon infection of an
invading pathogen is controlled by host
pattern recognition receptors (PRRs)* that
specifically recognise essential structural
components of infectious agents termed
pathogen-associated molecular patterns
(PAMPs) (1-3). Detection of PAMPs by
PRRs triggers intracellular signalling
pathways leading to the expression of
immune mediators such as cytokines,
chemokines and type I interferons (IFNs).
Toll-like receptors (TLRs) represent a now
well-defined PRR family, since much has
been discovered recently in terms of the
PAMPs they interact with, the downstream
signalling pathways triggered and the
complex yet specific immune responses
elicited.
Author's Homepage:
http://people.tcd.ie/agbowieDescription:
PUBLISHEDPMID: 18684710
Author: BOWIE, ANDREW
Type of material:
Journal ArticleCollections
Series/Report no:
The Journal of Biological Chemistry284
13
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Full text availableKeywords:
immune responseSubject (TCD):
Immunology, Inflammation & InfectionDOI:
http://dx.doi.org/10.1074/jbc.R800038200ISSN:
0021-9258Metadata
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