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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/63990

Title: TLR-dependent T cell activation in autoimmunity.
Author: MILLS, KINGSTON
Author's Homepage: http://people.tcd.ie/millsk
Keywords: autoimmunity
TLR
T cells
infection
PAMPs
DAMPS
Issue Date: 18-Nov-2011
Publisher: Nature
Citation: Mills KH, TLR-dependent T cell activation in autoimmunity., Nature Reviews Immunology, 11, 12, 2011, 807-22
Series/Report no.: Nature Reviews Immunology;11, 12
Abstract: Autoimmune disease can develop as a result of a breakdown in immunological tolerance, leading to the activation of self-reactive T cells. There is an established link between infection and human autoimmune diseases. Furthermore, experimental autoimmune diseases can be induced by immunization with autoantigens that are administered together with complete Freund’s adjuvant containing killed Mycobacteria tuberculosis, which in some cases can be replaced with individual pathogen-associated molecular patterns (PAMPs). Exogenous PAMPs and endogenous danger signals from necrotic cells bind to pathogen recognition receptors, including Toll-like receptors, and activate signaling pathways in innate immune cells and on T cells, leading to inflammatory cytokine production and T cell activation, and this is now considered to be a major factor in the development of autoimmunity.
Description: PUBLISHED
URI: http://hdl.handle.net/2262/63990
Appears in Collections:Biochemistry (Scholarly Publications)

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