Autophagy and cytokines
Citation:
Harris, J., Autophagy and cytokines, Cytokine, 56, 2, 2011, 140-144Download Item:
Abstract:
Autophagy is a highly conserved homoeostatic mechanism for the lysosomal degradation of cytosolic constituents, including long-lived macromolecules, organelles and intracellular pathogens. Autophagosomes are formed in response to a number of environmental stimuli, including amino acid deprivation, but also by both host- and pathogen-derived molecules, including toll-like receptor ligands and cytokines. In particular, IFN-?, TNF-?, IL-1, IL-2, IL-6 and TGF-? have been shown to induce autophagy, while IL-4, IL-10 and IL-13 are inhibitory. Moreover, autophagy can itself regulate the production and secretion of cytokines, including IL-1, IL-18, TNF-?, and Type I IFN. This review discusses the potentially pivotal roles of autophagy in the regulation of inflammation and the coordination of innate and adaptive immune responses.
Sponsor
Grant Number
Science Foundation Ireland
Author's Homepage:
http://people.tcd.ie/jaharrisDescription:
PUBLISHED
Author: HARRIS, JAMES
Type of material:
Journal ArticleCollections
Series/Report no:
Cytokine;56;
2;
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Full text availableKeywords:
Immunology, Infection, Inflammasome, MycobacteriaMetadata
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