SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses.
Item Type:Journal Article
Citation:Knosp CA, Carroll HP, Elliott J, Saunders SP, Nel HJ, Amu S, Pratt JC, Spence S, Doran E, Cooke N, Jackson R, Swift J, Fitzgerald DC, Heaney LG, Fallon PG, Kissenpfennig A, Johnston JA., SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses., Journal of Experimental Medicine, 208, 7, 2011, 1523-1531
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The incidence of allergy and asthma in developed countries is on the increase and this trend looks likely to continue. CD4+ T helper 2 (Th2) cells are major drivers of these diseases and their commitment is controlled by cytokines such as interleukin 4, which are in turn regulated by the suppressor of cytokine signaling (SOCS) proteins. We report that SOCS2?/? CD4+ T cells show markedly enhanced Th2 differentiation. SOCS2?/? mice, as well as RAG-1?/? mice transferred with SOCS2?/? CD4+ T cells, exhibit elevated type 2 responses after helminth antigen challenge. Moreover, in in vivo models of atopic dermatitis and allergen-induced airway inflammation, SOCS2?/? mice show significantly elevated IgE, eosinophilia, type 2 responses, and inflammatory pathology relative to wild-type mice. Finally, after T cell activation, markedly enhanced STAT6 and STAT5 phosphorylation is observed in SOCS2?/? T cells, whereas STAT3 phosphorylation is blunted. Thus, we provide the first evidence that SOCS2 plays an important role in regulating Th2 cell expansion and development of the type 2 allergic responses.
Medical Research Council (MRC)
Health Research Board (HRB)
Science Foundation Ireland (SFI)
Type of material:Journal Article
Series/Report no:Journal of Experimental Medicine
Availability:Full text available
Keywords:Respiratory disease, Allergy, atopic dermatitis, hyperresponsiveness, lung resistance, schistosome soluble egg antigen, suppressor of cytokine signaling
Subject (TCD):Immunology, Inflammation & Infection