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dc.contributor.authorFALLON, PADRAICen
dc.contributor.authorAMU, SYLVIEen
dc.contributor.authorSAUNDERS, SEANen
dc.contributor.authorNEL, HENDRIKen
dc.date.accessioned2011-08-09T08:49:16Z
dc.date.available2011-08-09T08:49:16Z
dc.date.issued2011en
dc.date.submitted2011en
dc.identifier.citationKnosp CA, Carroll HP, Elliott J, Saunders SP, Nel HJ, Amu S, Pratt JC, Spence S, Doran E, Cooke N, Jackson R, Swift J, Fitzgerald DC, Heaney LG, Fallon PG, Kissenpfennig A, Johnston JA., SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses., Journal of Experimental Medicine, 208, 7, 2011, 1523-1531en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/58445
dc.descriptionPUBLISHEDen
dc.descriptionPMID: 21646394en
dc.description.abstractThe incidence of allergy and asthma in developed countries is on the increase and this trend looks likely to continue. CD4+ T helper 2 (Th2) cells are major drivers of these diseases and their commitment is controlled by cytokines such as interleukin 4, which are in turn regulated by the suppressor of cytokine signaling (SOCS) proteins. We report that SOCS2?/? CD4+ T cells show markedly enhanced Th2 differentiation. SOCS2?/? mice, as well as RAG-1?/? mice transferred with SOCS2?/? CD4+ T cells, exhibit elevated type 2 responses after helminth antigen challenge. Moreover, in in vivo models of atopic dermatitis and allergen-induced airway inflammation, SOCS2?/? mice show significantly elevated IgE, eosinophilia, type 2 responses, and inflammatory pathology relative to wild-type mice. Finally, after T cell activation, markedly enhanced STAT6 and STAT5 phosphorylation is observed in SOCS2?/? T cells, whereas STAT3 phosphorylation is blunted. Thus, we provide the first evidence that SOCS2 plays an important role in regulating Th2 cell expansion and development of the type 2 allergic responses.en
dc.description.sponsorshipP.G. Fallon was supported by Science Foundation Ireland (07/IN1/B902) and National Children?s Research Centre. J.A. Johnston, A. Kissenpfennig, and J. Elliott were supported by the Department for Employment and Learning of Northern Ireland, The Welcome Trust (WT008532) and Health Research Board (Ireland; PD12008/01), and the MRC (UK; G1001795).en
dc.format.extent1523-1531en
dc.language.isoenen
dc.relation.ispartofseriesJournal of Experimental Medicineen
dc.relation.ispartofseries208en
dc.relation.ispartofseries7en
dc.rightsYen
dc.subjectRespiratory diseaseen
dc.subjectAllergyen
dc.subjectatopic dermatitisen
dc.subjecthyperresponsivenessen
dc.subjectlung resistanceen
dc.subjectschistosome soluble egg antigenen
dc.subjectsuppressor of cytokine signalingen
dc.titleSOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses.en
dc.typeJournal Articleen
dc.contributor.sponsorWellcome Trusten
dc.contributor.sponsorMedical Research Council (MRC)en
dc.contributor.sponsorHealth Research Board (HRB)en
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/pfallonen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/saundesen
dc.identifier.rssinternalid73961en
dc.contributor.sponsorGrantNumberWT008532en
dc.contributor.sponsorGrantNumberUK; G1001795en
dc.contributor.sponsorGrantNumberPD12008/01en
dc.contributor.sponsorGrantNumber07/IN1/B902en
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.identifier.rssurihttp://dx.doi.org/10.1084/jem.20101167en


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