T cells in multiple sclerosis and experimental autoimmune encephalomyelitis
Citation:
Fletcher, J.M., Lalor, S.J., Sweeney, C.M., Tubridy, N., Mills, K.H.G, T cells in multiple sclerosis and experimental autoimmune encephalomyelitis, Clinical and Experimental Immunology, 162, 1, 2010, 1-11Download Item:
Abstract:
Multiple sclerosis (MS) is a demyelinating inflammatory disorder of the
central nervous system (CNS), which involves autoimmune responses to
myelin antigens. Studies in experimental autoimmune encephalomyelitis
(EAE), an animal model for MS, have provided convincing evidence that T
cells specific for self-antigens mediate pathology in these diseases. Until
recently, T helper type 1 (Th1) cells were thought to be the main effector T
cells responsible for the autoimmune inflammation. However more recent
studies have highlighted an important pathogenic role for CD4+ T cells that
secrete interleukin (IL)-17, termed Th17, but also IL-17-secreting gd T cells in
EAE as well as other autoimmune and chronic inflammatory conditions. This
has prompted intensive study of the induction, function and regulation of
IL-17-producing T cells in MS and EAE. In this paper, we review the contribution
of Th1, Th17, gd, CD8+ and regulatory T cells as well as the possible
development of new therapeutic approaches for MS based on manipulating
these T cell subtypes.
Author's Homepage:
http://people.tcd.ie/millskhttp://people.tcd.ie/fletchj
http://people.tcd.ie/lalorst
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Clinical and Experimental Immunology162
1
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Immunology, Inflammation & Infection , NeuroscienceMetadata
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