A variant in the CD209 promoter is associated with the severity of liver disease in chronic Hepatitis C virus infection
Citation:
Elizabeth J. Ryan, Megan Dring, Cliona M. Ryan, Carol McNulty, Nigel J. Stevenson, Matthew W. Lawless, John Crowe, Niamh Nolan, John E. Hegarty and Cliona O'Farrelly, A variant in the CD209 promoter is associated with the severity of liver disease in chronic Hepatitis C virus infection, Human Immunology, 71, 8, 2010, 829-832Download Item:
A variant in the CD209 promoter is associated with the severity of liver disease in chronic Hepatitis C virus infection.pdf (Published (author's copy) - Peer Reviewed) 340.4Kb
Abstract:
CD209, a c-type lectin expressed by dendritic cells (DCs) acts as a pathogen recognition receptor. A single nucleotide polymorphism (SNP) in the promoter region of CD209 (-336 A/G; rs4804803) affects transcription and is associated with the severity of Tuberculosis and Dengue fever. As CD209 binds Hepatitis C Virus (HCV) glycoprotein-E2, we investigated this SNP in the context of chronic HCV infection. 131 Irish women who had received HCV contaminated Anti-D immunoglobulin and 79 healthy controls were genotyped. We found no association between rs4804803 and the risk of HCV chronicity. However, of those with chronic infection, possession of at least one g-allele was associated with more advanced liver disease, with significantly higher liver fibrosis scores and levels of alanine transaminase (ALT) observed. We conclude that rs4804803, a SNP in the CD209 promoter contributes to the severity of liver disease in chronic HCV infection.
Sponsor
Grant Number
Health Research Board (HRB)
Author's Homepage:
http://people.tcd.ie/ofarreclDescription:
PUBLISHED
Author: O'Farrelly, Cliona
Type of material:
Journal ArticleCollections:
Series/Report no:
Human Immunology71
8
Availability:
Full text availableKeywords:
Hepatitis C Virus, chronic viral infection, Biochemistry, BiochemistrySubject (TCD):
Immunology, Inflammation & InfectionLicences: