Browsing Physiology by Date of Publication
Now showing items 21-40 of 238
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The cellular protein level of Parkin is regulated by its ubiquitin-like domain
(2003)Parkin is a ubiquitin-protein isopeptide ligase (E3) involved in ubiquitin/proteasome-mediated protein degradation. Mutations in the parkin gene cause a loss-of-function and/or alter protein levels of parkin. As a result, ... -
Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta-induced inhibition of long-term potentiation in rat dentate gyrus
(2003)Lipopolysaccharide (LPS), a component of the cell wall of Gram-negative bacteria, has been shown to induce profound changes both peripherally and centrally. It has recently been reported that intraperitoneal injection of ... -
Physiological changes following a 12 week gym based stair-climbing, elliptical trainer and treadmill running program in females
(Minerva Medica, 2004)Despite the growing popularity of the elliptical trainer aerobic exercise modality the physiological changes induced following a training program using elliptical trainers remains unknown. Donne investigates the metabolic ... -
Internal models for bi-manual tasks
(2004)Co-ordinated bi-manual actions form the basis for many everyday motor skills. In this review, the internal model approach to the problem of bi-manual co-ordination is presented. Bi-manual coordinative tasks are often ... -
Influence of hormonal status, ageing and smoking on autonomic cardiovascular control and endothelial function
(Trinity College (Dublin, Ireland). Department of Physiology, 2004)Ageing, hypertension and smoking are known risk factors for cardiovascular disease. By contrast female sex hormones are known to have cardioprotective qualities ; however, their underlying mechanisms of action have yet to ... -
The cutaneous contribution to adaptive precision grip.
(2004)Only after injury, or perhaps prolonged exposure to cold that is sufficient to numb the fingers, do we suddenly appreciate the complex neural mechanisms that underlie our effortless dexterity in manipulating objects. The ... -
Regulation of synaptic strength & AMPA receptor subunit composition by PICK1
(2004)PICK1 (protein interacting with C kinase-1) regulates the surface expression of the AMPA receptor (AMPAR) GluR2 subunit, however,the functional consequences of this interaction are not well understood. Previous work has ... -
Functional expression of serotonin 5-HT7 receptor in human glioblastoma cell lines
(2004)Serotonin 5‐HT7 receptors are present in astrocytes. Understanding their role in this type of cell would greatly benefit from the identification of astroglial cell lines expressing this receptor type. The aim of the present ... -
The PDZ Domain of PICK1 Differentially Accepts Protein Kinase C-α and GluR2 as Interacting Ligands
(2004)The C terminus (ct) of protein kinase C-α (PKCα) has a type I PDZ binding motif, whereas GluR2 has a type II PDZ binding motif. Both motifs are recognized by the PDZ domain of protein interacting with protein kinase C ... -
Consensus analysis of Signal Peptide Peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared to Presenilins
(2004)The human genome encodes seven intramembrane-cleaving GXGD aspartic proteases. These are the two presenilins that activate signaling molecules and are implicated in Alzheimer's disease, signal peptide peptidase (SPP), ... -
Neuroprotective actions of eicosapentaenoic acid on lipopolysaccharide-induced dysfunction in rat hippocampus
(Wiley & Sons, 2004)Eicosapentaenoic acid (EPA) protects hippocampus from age-related and irradiation-induced changes that lead to impairment in synaptic function; the evidence suggests that this is due to its anti-inflammatory effects, ... -
System for performance measures of predictive grip in a dynamic haptic environment
(2004)Virtual environments provide a powerful means of experimentally examining object manipulation. In object manipulation a key issue is the coor- dination of grip force used to stabilize the object in the presence of load ... -
An investigation into the cellular and molecular signalling events which occur in [Beta]-amyloid-treated cultured cortical neurons
(Trinity College (Dublin, Ireland). Department of Physiology, 2004)Deposition of β-amyloid around neurons is a neuropathological hallmark of Alzheimer’s disease. The aim of this study was to investigate the cellular and molecular mechanisms underlying β-amyloid-mediated cell death in ... -
Characterisation of LTP induced by multiple spaced 200 Hz protocol in the rat dentate gyrus in vitro
(Trinity College (Dublin, Ireland). Department of Physiology, 2004)Long-term potentiation (LTP) in the hippocampus is believed to be a cellular correlate of learning and memory in the mammalian brain. Four different highfrequency stimulation (HFS) protocols were developed which induced ... -
Effects of smoking and ageing on cardiovascular function
(Trinity College (Dublin, Ireland). Department of Physiology, 2004)Ageing and smoking have both been identified as important risk factors for cardiovascular morbidity and mortality. The aim of these studies was to investigate the effects of ageing and smoking on autonomic and endothelial ... -
Analysis of the interaction between neurotrophins and cytokines with age
(Trinity College (Dublin, Ireland). Department of Physiology, 2004)Aging is associated with an increase in the concentration of the pro-inflammatory cytokine interleukin-1β in the hippocampus and cortex. This has been shown to have deleterious effects on the brain and specifically on a ... -
Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide
(2004)The mechanisms underlying the inhibition of long-term potentiation (LTP) induction by amyloid -peptide (A ) were investigated in the medial perforant path of the rat and mouse dentate gyrus in vitro . Evidence ... -
Ischaemia-reperfusion-induced renal injury : pathogenesis & modulation implications for transplantation
(Trinity College (Dublin, Ireland). Department of Physiology, 2004)Ischaemia-reperfusion is unavoidable during transplantation, but may promote allograft rejection. Preconditioning with a sub-lethal stress protects cells against a subsequent otherwise lethal stress, possibly through the ... -
Eye-Hand Coordination: Dextrous Object Manipulation in New Gravity
(ESA Publications Division, 2005) -
The effect of posture on muscle endurance, fatigue and blood flow
(Trinity College (Dublin, Ireland). Department of Physiology, 2005)Tilting the body from the supine to an upright position increases the time on a maximal graded cycle test by -1 5 % . However, this effect during constant-load cycling is unknown, and in addition, it is also unknown if ...