Ischaemia-reperfusion-induced renal injury : pathogenesis & modulation implications for transplantation
Citation:Karen Stokes, 'Ischaemia-reperfusion-induced renal injury : pathogenesis & modulation implications for transplantation', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2004, pp 409
Ischaemia-reperfusion is unavoidable during transplantation, but may promote allograft rejection. Preconditioning with a sub-lethal stress protects cells against a subsequent otherwise lethal stress, possibly through the induction of heat shock proteins. This thesis establishes a rat model of renal ischaemia-reperfusion injury and assesses the protective capability of several preconditioning methods. The most effective method was used to evaluate antigen expression and long-term protection.
Author: Stokes, Karen
Publisher:Trinity College (Dublin, Ireland). Department of Physiology
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Type of material:thesis
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