Resolution of inflammation: state of the art, definitions and terms
Item Type:Journal Article
Citation:Serhan CN, Brain SD, Buckley CD, Gilroy DW, Haslett C, O'neill LA, Perretti M, Rossi AG, Wallace JL, `Resolution of inflammation: state of the art, definitions and terms? in The FASEB Journal, 21, (2), 2006, pp 325 - 332
Resolution of inflammation - state of the art, definitions and terms.pdf (published (publisher copy) peer-reviewed) 314.2Kb
A recent focus meeting on Controlling Acute Inflammation was held in London, April 27-28, 2006, organized by D.W. Gilroy and S.D. Brain for the British Pharmacology Society. We concluded at the meeting that a consensus report was needed that addresses the rapid progress in this emerging field and details how the specific study of resolution of acute inflammation provides leads for novel anti-inflammatory therapeutics, as well as defines the terms and key components of interest in the resolution process within tissues as appreciated today. The inflammatory response protects the body against infection and injury but can itself become dysregulated with deleterious consequences to the host. It is now evident that endogenous biochemical pathways activated during defense reactions can counter-regulate inflammation and promote resolution. Hence, resolution is an active rather than a passive process, as once believed, which now promises novel approaches for the treatment of inflammation-associated diseases based on endogenous agonists of resolution.
Medical Research Council
National Institutes of Health (NIH)
Author: O'NEILL, LUKE ANTHONY JOHN
Publisher:The Federation of American Societies for Experimental Biology.
Type of material:Journal Article
Series/Report no:The FASEB Journal
Availability:Full text available