Browsing Chemistry by Subject "Cancer"
Now showing items 1-17 of 17
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Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones
(2010)A remarkably concise, chromatography-free route to the parent compound of the paullone family of cyclin-dependent kinase (CDK) inhibitors is reported. A similar strategy allowed the synthesis of the hitherto missing ... -
Design, synthesis, and biochemical evaluation of guanidine-based derivatives targeting protein kinases
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Kinases are some of the most intensively pursued classes of drug targets with approximately 243 distinct kinase inhibitors making it to human trials and most of these compounds are being investigated for the treatment of ... -
Enantioselective effect of cysteine functionalized mesoporous silica nanoparticles in U87 MG and GM08680 human cells and Staphylococcus aureus bacteria
(2021)Chirality is a fundamental phenomenon in biological systems, since most of the biomolecules and biological components and species are chiral and therefore recognize and respond differently depending on the enantiomer ... -
Folic acid modified gelatine coated quantum dots as potential reagents for in vitro cancer diagnostics.
(2011)BACKGROUND: Gelatine coating was previously shown to effectively reduce the cytotoxicity of CdTe Quantum Dots (QDs) which was a first step towards utilising them for biomedical applications. To be useful they also need ... -
Getting it right: 3D cell cultures for the assessment of photosensitizers for photodynamic therapy
(2015)Core quote “Cancer drug screening is rapidly moving towards the use of 3D cell models. The added complexity of PDT action makes this a conditio sine qua non for the screening of new photosensitizers.” -
Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment
(2020)Photodynamic therapy (PDT) is a promising cancer treatment which involves a photosensitizer (PS), light at a specific wavelength for PS activation and oxygen, which combine to elicit cell death. While the illumination ... -
Platelets, photosensitizers and PDT
(2013)Photodynamic therapy (PDT) has both direct cell and indirect vascular effects. Both are well established and the latter has given rise to specifically target angiogenesis in PDT treatments. While the vascular effects are ... -
Quaternarized pdppz: Synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation
(2011)The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and ... -
Ruthenium Polypyridyl Complexes for Biological Applications in Imaging and as Anti-Cancer Agents
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2018)Ruthenium-polypyridyl complexes containing extended aromatic ring systems exhibit attractive photophysical properties and have been shown to bind strongly to DNA. Such properties make complexes like these suitable for a ... -
Simple but powerful: Phenanthroline-based small molecules for cellular imaging and cancer screening
(2011)A two-step synthetic procedure gives highly fluorescent phenanthroline molecular probes. The compounds localize in the endoplasmic reticulum and their potential as bioactive probes was evaluated. The materials are quickly ... -
Specific Drug Formulation Additives: Revealing the Impact of Architecture and Block Length Ratio
(2015)Combining poly(ethylene glycol) (PEG) with sequence-defined peptides in PEG-peptide conjugates offers opportunities to realize next-generation drug formulation additives for overcoming undesired pharmacological profiles ... -
Strategies to Target Specific Components of the Ubiquitin Conjugation/Deconjugation Machinery
(2020)The regulation of ubiquitination status in the cell is controlled by ubiquitin ligases acting in tandem with deubiquitinating enzymes. Ubiquitination controls many key processes in the cell from division to death making ... -
Synthesis and biological evaluation of a library of glycoporphyrin compounds.
(2012)A library of glycosylated porphyrins (Glycoporphyrins) was prepared and evaluated for their PDT activity against oesophageal squamous cell carcinoma cell line OE21 in vitro. Synthetic methodology was developed to ... -
Synthesis, characterisation and biological evaluation of N-(ferrocenyl)naphthoyl amino acid esters as anticancer agents
(2010)A series of N-(ferrocenyl)naphthoyl amino acid esters 5?18 has been prepared by coupling ferrocenyl naphthoic acids 3?4 to ?-amino acids and linear amino acids in the presence of N-(3-dimethylaminopropyl)-N?-ethylcarbodiimide ... -
Transferrin conjugation does not increase the efficiency of liposomal Foscan during in vitro photodynamic therapy of oesophageal cancer
(2013)Photodynamic therapy (PDT) is based on the delivery of photocytotoxic agents to a target tissue, followed by irradiation. In order to increase the efficiency of PDT in oesophageal cancer therapy, polyethylene glycol ... -
An unusual glycosylation product from a partially protected fucosyl donor under silver triflate activation conditions.
(2013)Partially protected glycosyl donors are extremely useful reagents for oligosaccharide synthesis allowing more facile deprotection and enhanced activity due to lower steric restraints. A partially protected fucosyl donor ...