Synthesis and biological evaluation of a library of glycoporphyrin compounds.
Item Type:Journal Article
Citation:Daly R, Vaz G, Davies AM, Senge MO, Scanlan EM, Synthesis and biological evaluation of a library of glycoporphyrin compounds., Chemistry (Weinheim an der Bergstrasse, Germany), 18, 46, 2012, 14671-9
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A library of glycosylated porphyrins (Glycoporphyrins) was prepared and evaluated for their PDT activity against oesophageal squamous cell carcinoma cell line OE21 in vitro. Synthetic methodology was developed to allow incorporation of biologically active carbohydrates including the histo blood group antigen trisaccharide, Lewis x onto the porphyrin backbone. The effect of the carbohydrate group and substitution pattern on the PDT activity, cell uptake and subcellular localisation of the glycoporphyrin compounds is reported.
PubMed ID: 23018896
Type of material:Journal Article
Series/Report no:Chemistry (Weinheim an der Bergstrasse, Germany)
Availability:Full text available