Quaternarized pdppz: Synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation

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Item Type:
Journal Article
Date:
2011
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Citation:
Robert B. P. Elmes, Marialuisa Erby, Suzanne M. Cloonan, Susan J. Quinn, D. Clive Williams and Thorfinnur Gunnlaugsson, Quaternarized pdppz: Synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation, Chemical Communications, 47, 2011, 686 - 688
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Abstract:
The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and induced apoptosis upon light irradiation in various cancer cell lines after 24 hours of incubation.
URI:
http://hdl.handle.net/2262/64079
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Grant Number
Science Foundation Ireland (SFI)
SFI RFP 2009
Higher Education Authority (HEA)
Irish Research Council for Science and Engineering Technology (IRCSET)
Author's Homepage:
http://people.tcd.ie/dwillims
http://people.tcd.ie/gunnlaut
http://people.tcd.ie/cloonas
Description:
PUBLISHED
Author: Williams, David; Gunnlaugsson, Thorfinnur; Cloonan, Suzanne
Type of material:
Journal Article
URI:
http://hdl.handle.net/2262/64079
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Series/Report no:
Chemical Communications
47
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Full text available
Keywords:
quaternarized pdppz derivative 1, dppz derivative, cellular death, apoptosis
Subject (TCD):
Cancer
DOI:
http://dx.doi.org/10.1039/C0CC04303F
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