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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/64079

Title: Quaternarized pdppz: Synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation
Author: GUNNLAUGSSON, THORFINNUR
WILLIAMS, DAVID CLIVE
Sponsor: 
Name Grant Number
SFI RFP 2009

Author's Homepage: http://people.tcd.ie/dwillims
http://people.tcd.ie/gunnlaut
Keywords: quaternarized pdppz derivative 1
dppz derivative
cellular death
apoptosis
Issue Date: 2011
Citation: Robert B. P. Elmes, Marialuisa Erby, Suzanne M. Cloonan, Susan J. Quinn, D. Clive Williams and Thorfinnur Gunnlaugsson, Quaternarized pdppz: Synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation, Chemical Communications, 47, 2011, 686 - 688
Series/Report no.: Chemical Communications
47
Abstract: The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and induced apoptosis upon light irradiation in various cancer cell lines after 24 hours of incubation.
Description: PUBLISHED
URI: http://hdl.handle.net/2262/64079
Appears in Collections:Chemistry (Scholarly Publications)

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