Simple but powerful: Phenanthroline-based small molecules for cellular imaging and cancer screening

File Type:
PDFItem Type:
Journal ArticleDate:
2011Citation:
Natalia N. Sergeeva, Marion Donnier-Marechal, Gisela M. Vaz, Anthony M. Davies, Mathias O. Senge, Simple but powerful: Phenanthroline-based small molecules for cellular imaging and cancer screening, Bioorganic & Medicinal Chemistry Letters, 21, 15, 2011, 4385-4388Download Item:

Abstract:
A two-step synthetic procedure gives highly fluorescent phenanthroline molecular probes. The compounds localize in the endoplasmic reticulum and their potential as bioactive probes was evaluated. The materials are quickly taken up by living cells within 5 min. Preliminary in vitro studies have shown that these compounds are selective to esophageal cancer cells and can be used as selective markers in intracellular cancer diagnostics. The materials show a remarkable cytotoxicity towards cancer cells vs. normal as 7 to 1.
Sponsor
Grant Number
Health Research Board (HRB)
TRA/2007/11
Science Foundation Ireland (SFI)
09/IN.1/B2650
Author's Homepage:
http://people.tcd.ie/sengemhttp://people.tcd.ie/amitche
Description:
PUBLISHEDType of material:
Journal ArticleCollections:
Series/Report no:
Bioorganic & Medicinal Chemistry Letters21
15
Availability:
Full text availableKeywords:
Oncology, Esophageal cancerSubject (TCD):
CancerLicences: