Browsing Immunology by Date of Publication
Now showing items 1-20 of 50
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Defiency of natural killer receptor expressing cells in haemophagocytic lymphohistiocytosis
(Trinity College (Dublin, Ireland). Department of Immunology, 2002)Two children, patient A and patient B, were diagnosed on clinical and histological grounds to have haemophagocytic lymphohistiocytosis (HLH) (Henter et al. 1991a; Arico et al. 2001a). Clinical presentation of HLH consists ... -
Hepatic haematopoietic stem cells and the T Cell development potential of the adult human liver
(Trinity College (Dublin, Ireland). Department of Immunology, 2002)Large populations of innate T cells are found in the normal adult human liver (AHL), some of which may differentiate locally. The AHL also contains populations of functional myeloid and erythroid progenitors. The co-expression ... -
Analysis of the autoantibody response directed against tissue transglutaminase in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2006)Coeliac disease is an inflammatory disease of the proximal small intestine caused by wheat gluten ingestion in genetically susceptible individuals. The mucosal pathology in coeliac disease is characterised by villous ... -
Molecular events following gluten stimulation in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2006)Coeliac disease is a common autoimmune disorder, caused by an intolerance to dietary gluten in genetically predisposed individuals. Despite the advances in understanding of the nature of the disease, it remains unknown how ... -
Characterisation of gut mucosa in patients with potential coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2007)Coeliac disease is a gluten dependent enteropathy with a high incidence and increased risk of mortality. Diagnosis of coeliac disease is based on a biopsy of small intestine. However, it is now believed that many individuals ... -
Design, optimisation and functional relevance of in silico tools for the study of coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2008)Peptide-MHC interaction is a crucial pre-requisite for the recognition of antigen by T cells. It has long been recognised that peptides with a high affinity for MHC molecules are more likely to elicit a pronounced T cell ... -
Innate immunity and coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2008)Coeliac disease is a gluten sensitive enteropathy in which well defined gliadin peptides initiate a T cell mediated inflammatory response within the small intestine. This disseminates into destruction of the villous ... -
Preferential Th1 Cytokine Profile of Phosphoantigen-Stimulated Human V?9V?2 T Cells
(Hindawi, 2010)Human V?9V?2 T cells recognise pyrophosphate-based antigens (phosphoantigens) and have multiple functions in innate and adaptive immunity, including a unique ability to activate other cells of the immune system. We used ... -
Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis.
(Springer, 2011)AIMS/HYPOTHESIS: The innate immune cells, invariant natural killer T cells (iNKT cells), are implicated in the pathogenesis of psoriasis, an inflammatory condition associated with obesity and other metabolic diseases, ... -
Distinct and Overlapping Effector Functions of Expanded Human CD4, CD8? and CD4CD8? Invariant Natural Killer T Cells
(2011)CD1d-restricted invariant natural killer T (iNKT) cells have diverse immune stimulatory/regulatory activities through their ability to release cytokines and to kill or transactivate other cells. Activation of iNKT cells ... -
Regulation of B cell function by human invariant natural killer T cells in health and autoimmune disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2011)Invariant natural killer T (iNKT) cells are a subset of innate T lymphocytes that express a semi-invariant T cell receptor that recognises glycolipids presented on CD1d by antigen- presenting cells. They have the unique ... -
Evolutionary origins and functions of Schistosoma mansoni Pellino
(Trinity College (Dublin, Ireland). Department of Immunology, 2012)The immune system of modern man has innate signalling pathways that arose in ancestral species. This is exemplified by the discovery of the Toll-like receptor (TLR) pathway using free-living model organisms, specifically ... -
Identification of Schistosoma mansoni adult male worm excretome-secretome and production of recombinant proteins with immunomodulatory potential
(Trinity College (Dublin, Ireland). Department of Immunology, 2012)Over two billion people worldwide are infected with helminth parasites. Helminths strongly modulate the host’s immune response in order to establish a balanced parasite- host dynamic. This helminth-derived immunomodulatory ... -
Persistent Changes in Circulating and Intestinal gamma delta T Cell Subsets, Invariant Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Children and Adults with Coeliac Disease
(2013)Coeliac disease is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals. The only current therapy is a lifelong gluten free diet. While ... -
Characterising Cytokine Gene Expression Signatures in Patients with Severe Sepsis
(2013)Introduction. Severe sepsis in humans may be related to an underlying profound immune suppressive state. We investigated the link between gene expression of immune regulatory cytokines and the range of illness severity in ... -
Characterisation of mouse strains with spontaneous mutations, leading to epidermal barrier dysfunction and inflammation
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Atopic dermatitis is a chronic pruritic skin disease, associated with eczematous lesions, epidermal barrier dysfunction, and Immunoglobulin-E-mediated sensitization to food and environmental allergens. The complex ... -
Immune variation in idiopathic bronchiectasis
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Bronchiectasis is a chronic suppurative lung disease. It is the pathological end-point of many disease processes including cystic fibrosis and antibody deficiency. In many cases of bronchiectasis, termed 'idiopathic', no ... -
Immune responses to tissue transglutaminase in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Coeliac disease is a common inflammatory disease of the small intestine caused by an inappropriate immune response to wheat gluten and gliadin in genetically predisposed individuals. Investigation into the pathogenesis of ... -
The characterisation of peripheral blood and intestinal antigen presenting cells in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Antigen presenting cells, part of the innate immune system, play a central role in initiating and modulating the adaptive immune response. Coeliac disease is caused by aberrant activity of T cells specific for the dietary ... -
Investigation of the phenotypes, functions and therapeutic potential of expanded human invariant natural killer T cell subsets
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Invariant natural killer T (iNKT) cells comprise a rare subset of T cells that recognise glycolipid antigens presented by CDld. Activation of iNKT cells in mice leads to protection against cancer, autoimmune disease and ...