Browsing Genetics (Theses and Dissertations) by Subject "ALS"

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    • Detection of pleiotropic repeat expansions and their oligogenic contribution to amyotrophic lateral sclerosis 

      Hengeveld, Jennifer Christine (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)
      This thesis aims to advance our understanding of the genetic mechanisms that contribute to amyotrophic lateral sclerosis (ALS). The focus is on investigating pleiotropy in genetic contributors to ALS by examining the ...

    • On the Use of Machine Learning in Genomic Prediction 

      Kelly, Ciaran (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)
      This thesis explores the use of machine learning in the context of genomic prediction and the issue of confounding in such approaches. Traditionally, genomic prediction methods have made use of linear models with much ...