Browsing Clinical Medicine (Scholarly Publications) by Title
Now showing items 509-528 of 638
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Response: Disseminated tuberculosis.
(Oxford University Press, 2017)Lymphopaenia is described among patients with tuberculosis.The lymphocyte count for the patient in our publication prior to treatment was 0.8 (1–2 1016ml). At the time of writing, he is still receiving his anti-tuberculous ... -
Retrospective analysis of attitudes to ageing in the Economist: apocalyptic demography for opinion formers.
(2009)Objective To investigate the description of older people and ageing in a major weekly newspaper, influential in political and financial circles, to see whether it reflected ageing in a balanced manner, and to what extent ... -
Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism.
(2006)Background? Meta-analyses predict that a 25% lowering of plasma homocysteine would reduce the risk of coronary heart disease by 11% to 16% and stroke by 19% to 24%. Individuals homozygous for the methylenetetrahydrofolate ... -
Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine
(2014)Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase red uctase (MTRR), riboflavin- dependent enzymes, participat e in homocysteine metabolism. Reported effects of riboflavin status on the ... -
Risk management framework for nano-biomaterials used in medical devices and advanced therapy medicinal products
(2020)The convergence of nanotechnology and biotechnology has led to substantial advancements in nano-biomaterials (NBMs) used in medical devices (MD) and advanced therapy medicinal products (ATMP). However, there are concerns ... -
A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.
(2013)Type 2 innate lymphoid cells (ILC2s, nuocytes, NHC) require RORA and GATA3 for their development. We show that human ILC2s express skin homing receptors and infiltrate the skin after allergen challenge, where they produce ... -
A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins.
(2011)Clostridium difficile is the etiological agent of antibiotic-associated diarrhoea (AAD) and pseudomembranous colitis in humans. The role of the surface layer proteins (SLPs) in this disease has not yet been fully explored. ... -
The role of chemokines in acute and chronic hepatitis C infection.
(2014)Hepatitis C imposes a significant burden on global healthcare. Chronic infection is associated with progressive inflammation of the liver which typically manifests in cirrhosis, organ failure and cancer. By virtue of ... -
?The role of energy metabolism in driving disease progression in inflammatory, hypoxic and angiogenic microenvironments'.
(2015)Cellular metabolism plays a crucial role in primed inflammatory, hypoxic and angiogenic microenvironments by supporting disease progression in a range of disease entities. To adapt to fluctuating stress-induced ... -
The role of epigenetics in resistance to cisplatin chemotherapy in lung cancer
(2011)Non-small cell lung cancer (NSCLC) is the most common cause of cancer related death in the world. Cisplatin and carboplatin are the most commonly used cytotoxic chemotherapeutic agents to treat the disease. These agents, ... -
The Role of Epigenetics in Resistance to Cisplatin Chemotherapy in Lung Cancer
(2011)Non-small cell lung cancer (NSCLC) is the most common cause of cancer related death in the world. Cisplatin and carboplatin are the most commonly used cytotoxic chemotherapeutic agents to treat the disease. These agents, ... -
Role of Notch signaling in regulating innate immunity and inflammation in health and disease
(2016)The Notch signaling pathway is conserved from Droso- phila to mammals and is critically involved in develop- mental processes. In the immune system, it has been established that Notch signaling regulates multiple steps ... -
RSOS submission raw data
(RSOS, 2017) -
SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration
(2022)SARM1 (sterile alpha and armadillo motif-containing protein) is a highly conserved Toll/IL-1 Receptor (TIR) adaptor with important roles in mediating immune responses. Studies in the brain have shown that SARM1 plays a ... -
SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer
(2016)Expression of the SASH1 protein is reduced in a range of human cancers and has been implicated in apoptotic cancer cell death. This study investigated whether increasing SASH1 expression could be a useful therapeutic ... -
Schistosoma "Eggs-Iting" the Host: Granuloma Formation and Egg Excretion.
(2018)Schistosomiasis is a major cause of morbidity in humans invoked by chronic infection with parasitic trematodes of the genus Schistosoma. Schistosomes have a complex life-cycle involving infections of an aquatic snail ... -
The schistosoma granuloma: friend or foe?
(2013)Infection of man with Schistosoma species of trematode parasite causes marked chronic morbidity. Individuals that become infected with Schistosomes may develop a spectrum of pathology ranging from mild cercarial dermatitis ... -
Schistosoma mansoni secretes a chemokine binding protein with anti-inflammatory activity.
(Rockefeller University Press, 2005)The coevolution of humans and infectious agents has exerted selective pressure on the immune system to control potentially lethal infections. Correspondingly, pathogens have evolved with various strategies to modulate and ... -
Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages
(The Journal of Immunology, 2004)Infectious pathogens can selectively stimulate activation or suppression of T cells to facilitate their survival within humans. In this study we demonstrate that the trematode parasite Schistosoma mansoni has evolved with ...