Browsing Biochemistry (Scholarly Publications) by Subject "Cancer"
Now showing items 1-20 of 70
-
2-Deoxy-D-Glucose inhibits aggressive triple-negative breast cancer cells by targeting glycolysis and the cancer stem cell phenotype
(2019)Due to limited availability of pharmacological therapies, triple-negative breast cancer (TNBC) is the subtype with worst outcome. We hypothesised that 2-Deoxy-D-Glucose (2-DG), a glucose analogue, may hold potential as a ... -
Advances in immunotherapy for the treatment of glioblastoma.
(2017)Glioblastoma (GBM) is an aggressive brain tumour, associated with extremely poor prognosis and although there have been therapeutic advances, treatment options remain limited. This review focuses on the use of immunotherapy, ... -
Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer - Novel Diagnostic and Therapeutic Potential.
(2015)Caspases are a group of proteolytic enzymes involved in the co-ordination of cellular processes, including cellular homeostasis, inflammation and apoptosis. Altered activity of caspases, particularly caspase-1, has ... -
Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells
(2013)The immune system has evolved regulatory mechanisms to control immune responses to self-antigens. Regulatory T (Treg) cells play a pivotal role in maintaining immune tolerance, but tumour growth is associated with local ... -
Building unique bonds to fight misplaced DNA
(2013)A cyclic dinucleotide comprised of GMP and AMP was previously shown to be a key intermediate during activation of innate immune responses to cytosolic DNA. A report by Patel and Tuschl groups published in Cell reveals the ... -
Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis
(2019)Murine inflammatory caspase-11 has an important role in intestinal epithelial inflammation and barrier function. Activation of the non-canonical inflammasome, mediated by caspase-11, serves as a regulatory pathway for the ... -
Characterizing caspase-1 involvement during esophageal disease progression.
(2020)Barrett’s esophagus (BE) is an inflammatory condition and a neoplastic precursor to esophageal adenocarcinoma (EAC). Inflammasome signaling, which contributes to acute and chronic inflammation, results in caspase-1 activation ... -
Diverse Immunoregulatory Roles of Oxysterols - The Oxidized Cholesterol Metabolites
(2020)Intermediates of both cholesterol synthesis and cholesterol metabolism can have diverse roles in the control of cellular processes that go beyond the control of cholesterol homeostasis. For example, oxidized forms of ... -
Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1 alpha-dependent inflammation.
(2014)Obesity is characterized by chronic inflammation associated with neutrophil and M1 macrophage infiltration into white adipose tissue. However, the mechanisms underlying this process remain largely unknown. Based on the ... -
Enrichment of inflammatory IL-17 and TNF-α secreting CD4+ T cells within colorectal tumours despite the presence of elevated CD39+ T regulatory cells and increased expression of the immune checkpoint molecule, PD-1.
(2016)T cell infiltration into colorectal tumors has been shown to correlate with improved patient outcomes. However, more detailed information on the makeup and relationships between the infiltrating T cell subsets is lacking. ... -
Epithelial expression of inflammatory caspases-4 and -5 is specific to malignancy in colorectal cancer patients.
(American Gastroenterology Association (AGA), 2016) -
Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3.
(2004)We detected a protein in rabbit skeletal muscle extracts that was phosphorylated rapidly by SGK1 (serum- and glucocorticoid- induced kinase 1), but not by protein kinase B ? , and identified it as NDRG2 (N-myc ... -
FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation.
(2014)Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal dominant condition caused by mutations in the FLCN gene and characterized by benign hair follicle tumors, pneumothorax, and renal cancer. Folliculin (FLCN), the protein ... -
A highly efficient blocked Gibbs sampler reconstruction of multidimensional NMR spectra
(2010)Projection Reconstruction Nuclear Magnetic Resonance (PR-NMR) is a new technique to generate multi-dimensional NMR spectra, which have discrete features that are relatively sparsely distributed in space. A small number ... -
Identification of filamin C as a new physiological substrate of PKBalpha using KESTREL.
(2004)We detected a protein in rabbit skeletal muscle extracts that was phosphorylated rapidly by PKB ? (protein kinase B ? ), but not by SGK1 (serum- and glucocorticoid-induced kinase 1), and ident- ified it as the ... -
Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines.
(2013)Vaccines that promote protective adaptive immune responses have been successfully developed against a range of infectious diseases, and these are normally administered prior to exposure with the relevant virus or bacteria. ...