Browsing Biochemistry (Scholarly Publications) by Author "O'Farrelly, Cliona"
Now showing items 1-11 of 11
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Chronic hepatitis C infection blocks the ability of dendritic cells to secrete IFN-α and stimulate T-cell proliferation
Stevenson, Nigel; O'Farrelly, Cliona (2011)Dendritic cells (DCs) are likely to play a key rolein the compromised T-cell function associated with hepatitis C Virus (HCV) infection. However, studies of DC function inHCV-infected patients to date have yielded conflicting ... -
Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1 alpha-Dependent Inflammation
O'Farrelly, Cliona; Mok, Kenneth; Lavelle, Edward; Lynch, Lydia (2014)Obesity is characterized by chronic inflammation associated with neutrophil and M1 macrophage infiltration into white adipose tissue. However, the mechanisms underlying this process remain largely unknown. Based on the ... -
HIV-1 Promotes the Degradation of Components of the Type 1 IFN JAK/STAT Pathway and Blocks Anti-viral ISG Induction
Stevenson, Nigel; O'Farrelly, Cliona (2018) -
Improved detection of biomarkers in cervico-vaginal mucus (CVM) from postpartum cattle
O'Farrelly, Cliona; Adnane, Mounir; Kelly, Paul; Chapwanya, Aspinas; Meade, Kieran (2018)Background: In the postpartum cow, early diagnosis of uterine disease is currently problematic due to the lack of reliable, non-invasive diagnostic methods. Cervico-vaginal mucus (CVM) is an easy to collect potentially ... -
Non-canonical inflammasome-mediated IL-1β production by primary endometrial epithelial and stromal fibroblast cells is NLRP3 and caspase-4 dependent
O'Farrelly, Cliona; Kelly, Paul; Meade, Kieran G. (2019)Inflammation of the post-partum uterus is a normal physiological event, crucial for tissue involution and repair. However, in the bovine, some cows fail to resolve this inflammation, resulting in endometritis, which ... -
β-Defensins: Farming the microbiome for homeostasis and health
O'Farrelly, Cliona; Meade, Kieran (2019)Diverse commensal populations are now regarded as key to physiological homeostasis and protection against disease. Although bacteria are the most abundant component of microbiomes, and the most intensively studied, the ...