Browsing Biochemistry (Scholarly Publications) by Author "Lee, Jun Hee"

Now showing items 1-3 of 3

    • Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. 

      Budanov, Andrei; Lee, Jun Hee; Talukdar, Saswata; Park, Eek Joong; Park, Hae Li; Park, Hwan-Woo; Bandyopadhyay, Gautam; Li, Ning; Aghajan, Mariam; Jang, Insook; Wolfe, Amber M.; Perkins, Guy A.; Ellisman, Mark H.; Bier, Ethan; Scadeng, Miriam; Foretz, Marc; Viollet, Benoit; Olefsky, Jerrold; Karin, Michael (2012)
      Chronic activation of mammalian target of rapamycin complex 1 (mTORC1) and p70 S6 kinase (S6K) in response to hypernutrition contributes to obesity-associated metabolic pathologies, including hepatosteatosis and insulin ...

    • Sestrins orchestrate cellular metabolism to attenuate aging 

      Budanov, Andrei; Lee, Jun Hee; Karin, Michael (2013)
      The Sestrins constitute a family of evolutionarily conserved stress-inducible proteins that suppress oxidative stress and regulate AMP-dependent protein kinase (AMPK)-mammalian target of rapamycin (mTOR) signaling. By ...

    • Stressin' Sestrins take an aging fight 

      Budanov, Andrei; Lee, Jun Hee; Karin, Michael (2010)
      Sestrins (Sesns) are a family of highly conserved stress‐responsive proteins, transcriptionally regulated by p53 and forkhead transcription factor that exhibit oxidoreductase activity in vitro and can protect cells from ...