Sestrins orchestrate cellular metabolism to attenuate aging
Item Type:Journal Article
Citation:Lee, J.H., Budanov, A.V. & Karin, M., Sestrins orchestrate cellular metabolism to attenuate aging, Cell Metabolism, 18, 6, 2013, 792 - 801
Budanov-CellMet-rev-2013.pdf (PDF) 564.3Kb
The Sestrins constitute a family of evolutionarily conserved stress-inducible proteins that suppress oxidative stress and regulate AMP-dependent protein kinase (AMPK)-mammalian target of rapamycin (mTOR) signaling. By virtue of these activities, the Sestrins serve as important regulators of metabolic homeostasis. Accordingly, inactivation of Sestrin genes in invertebrates resulted in diverse metabolic pathologies, including oxidative damage, fat accumulation, mitochondrial dysfunction, and muscle degeneration, that resemble accelerated tissue aging. Likewise, Sestrin deficiencies in mice led to accelerated diabetic progression upon obesity. Further investigation of Sestrin function and regulation should provide new insights into age-associated metabolic diseases, such as diabetes, myopathies, and cancer.
Type of material:Journal Article
Series/Report no:Cell Metabolism;
Availability:Full text available