Browsing Biochemistry (Scholarly Publications) by Author "LAVELLE, EDWARD"
Now showing items 1-20 of 28
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Advances in immunotherapy for the treatment of glioblastoma.
LAVELLE, EDWARD (2017)Glioblastoma (GBM) is an aggressive brain tumour, associated with extremely poor prognosis and although there have been therapeutic advances, treatment options remain limited. This review focuses on the use of immunotherapy, ... -
Autophagy in the immune response to tuberculosis: clinical perspectives
KEANE, JOSEPH; HARRIS, JAMES; LAVELLE, EDWARD; NI CHEALLAIGH, CLIONA; Hope, J.C. (2011)A growing body of evidence points to autophagy as an essential component in the immune response to tuberculosis. Autophagy is a direct mechanism of killing intracellular Mycobacterium tuberculosis and also acts as a modulator ... -
Delivery strategies to enhance oral vaccination against enteric infections
LAVELLE, EDWARD (2015)While the majority of human pathogens infect the body through mucosal sites, most licensed vaccines are injectable. In fact the only mucosal vaccine that has been widely used globally for infant and childhood vaccination ... -
Editorial: Immune cells in the mucosa
LAVELLE, EDWARD (2016)The importance of autophagy as a key regulator of cellular homeostasis and responsiveness to stress and infection is being increasingly appreciated as reflected in the recent award of the Nobel Prize in Physiology or ... -
Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent
MILLS, KINGSTON; LAVELLE, EDWARD; ARMSTRONG, MICHELLE (2004)Adenylate cyclase toxin (CyaA) from Bordetella pertussis can subvert host immune responses allowing bacterial colonization. Here we have examined its adjuvant and immunomodulatory properties and the possible contribution ... -
Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1 alpha-dependent inflammation.
O'FARRELLY, CLIONA; LAVELLE, EDWARD; CAMPBELL, MATTHEW; MOK, KENNETH (2014)Obesity is characterized by chronic inflammation associated with neutrophil and M1 macrophage infiltration into white adipose tissue. However, the mechanisms underlying this process remain largely unknown. Based on the ... -
Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages
LAVELLE, EDWARD (2016)Background: Particulate matter has been shown to stimulate the innate immune system and induce acute inflammation. Therefore, while nanotechnology has the potential to provide therapeutic formulations with improved efficacy, ... -
Fas/CD95-Induced Chemokines Can Serve as "Find-Me" Signals for Apoptotic Cells.
LAVELLE, EDWARD; MARTIN, SEAMUS JOSEPH (2013)Apoptosis is commonly thought to represent an immunologically silent or even anti-inflammatory mode of cell death, resulting in cell clearance in the absence of explicit activation of the immune system. However, here ... -
Granzyme B-dependent proteolysis acts as a switch to enhance the pro-inflammatory activity of IL-1
LAVELLE, EDWARD; MARTIN, SEAMUS (2011)Granzyme B is a cytotoxic lymphocyte-derived protease that plays a central role in promoting apoptosis of virus-infected target cells, through direct proteolysis and activation of constituents of the cell death machinery. ... -
Harnessing the antibacterial and immunological properties of mucosal-associated invariant T cells in the development of novel oral vaccines against enteric infections.
LAVELLE, EDWARD (2014)Enteric infections are a major cause of mortality and morbidity with significant social and economic implications worldwide and particularly in developing countries. An attractive approach to minimizing the impact of these ... -
Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune disease.
LAVELLE, EDWARD; MILLS, KINGSTON; LALOR, STEPHEN (2009)IL-17 producing CD4+ T (Th17) cells are pathogenic in many autoimmune diseases. The induction and expansion of Th17 cells is directed by cytokines, including IL-23 and IL-1?, produced by innate immune cells through ... -
Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.
LAVELLE, EDWARD; MILLS, KINGSTON; LALOR, STEPHEN (2009)Th17 cells, CD4(+) T cells that secrete interleukin-17 (IL-17), are pathogenic in autoimmune diseases and their development and expansion is driven by the cytokines IL-6, TGF-beta, IL-21, IL-1, and IL-23. However, there ... -
Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract.
LAVELLE, EDWARD (2013)Developing efficacious vaccines against enteric diseases is a global challenge that requires a better understanding of cellular recruitment dynamics at the mucosal surfaces. The current paradigm of T cell homing to the ... -
Mistletoe lectins enhance immune responses to intranasally co-administered herpes simplex virus glycoprotein D2.
LAVELLE, EDWARD; MILLS, KINGSTON (Blackwell, 2002)The mucosal adjuvant properties of the three type 2 ribosome-inactivating proteins (RIPs) from the European mistletoe, Viscum album L., were investigated. Mistletoe lectins were compared with cholera toxin (CT) as adjuvants ...