Browsing Biochemistry (Theses and Dissertations) by Subject "anti-trypnosomal, cysteine protease inhibitor, drug repurposing, Fingolimod, S1P, SPK-843, Amphotericin B"
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Development of Novel Anti-Trypanosomal Compounds via Computational, In Vitro and In Vivo Methods
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Human African Trypanosomiasis is a neglected parasitic disease caused by Trypanosoma brucei, which if left untreated eventually leads to coma and death. With no successful vaccine to date, treatment relies on chemotherapy. ...