Browsing Biochemistry (Theses and Dissertations) by Subject "Immunometabolism"
Now showing items 1-6 of 6
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Citrate, oxaloacetate and 2-hydroxyglutarate in the control of inflammatory macrophage activation
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Immunometabolism is the study of changes that occur in the metabolic pathways of an immune cell during its activation. For macrophages, the remodelling of their metabolism following activation supports the adoption of ... -
Effect of small molecules modulators of Complex III of the electron transport chain on cytokine production in macrophages
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Innate immune cells promote inflammation when activated by Pathogen- associated molecular patterns (PAMPs) and initiate the immune response to stress and microbial invasion. When macrophages are primed with the ... -
The Immunomodulatory Metabolite Itaconate Regulates NLRP3 Inflammasome Activation and Type I Interferon Signalling
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)The NLRP3 inflammasome is a multi-protein complex which activates caspase-1 for the cleavage and release of mature IL-1β and IL-18. Caspase-1 also cleaves gasdermin D, driving a process called pyroptosis. Results from ... -
NK1.1 receptor ligation or tumour interactions prime NK cells for IL2-mediated metabolic and functional responses
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)Natural Killer (NK) cells undergo a distinct metabolic response following cytokine stimulation, which involves increased rates of glycolysis and oxidative phosphorylation (OxPhos). This metabolic response is essential for ... -
PKM2 regulation of metabolism but not transcription is important for natural killer cell responses
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating signal transduction and cellular metabolism is essential for effective NK cells responses. The PKM2 isoform of the ... -
Sterol Regulatory Element Binding Proteins; Central Metabolic Regulators of Natural Killer Cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Natural killer (NK) cells have important functions in the immune response against pathogen- infected and transformed cells. NK cell metabolism is crucial for NK cell effector functions. In this study sterol regulatory ...