Browsing Biochemistry (Theses and Dissertations) by Subject "Biochemstry, Ph.D."
Now showing items 1-4 of 4
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Cancer cell bioenergetics in response to anti-cancer agents
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Altered metabolism is a hallmark of cancer (Hanahan and Weinberg, 2011) and while genetic and molecular modifications have enabled cancers to survive the onslaught of various cancer therapies (Pillai et al., 2010), changes ... -
Development of novel pyrrolo-1,5-benzoxazepines as anti-cancer agents for the treatment of chronic myeloid leukaemia
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)Chronic myeloid leukaemia (CML) is characterised by the presence of a constitutively active tyrosine kinase known as Bcr-Abl. The Bcr-Abl kinase inhibitor, STI571, is the first line treatment for CML, but the recent emergence ... -
Mal is not esential for TLR2 signalling and inhibits signalling by TLR3
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)This thesis set out to systematically analyse the role of Mai in signalling by TLR2, TLR3 and TLR4 in murine macrophages and dendritic cells. It has revealed that Mai is not essential to TLR2 signal transduction, is required ... -
Studies on the relationship between metabolism and control of N-linked Glycosylation in CHO cells
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)The process of post-translational attachment of oligosaccharide structures to asparagine residues in nascent polypeptides is termed N-linked glycosylation. These glycan structures can influence the folding, stability, ...