Browsing Biochemistry (Theses and Dissertations) by Sponsor "Trinity College Dublin (TCD)"
Now showing items 1-9 of 9
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Characterisation of the immune response to calcium phosphate particulates; implications for osteoarthritis and bone tissue engineering
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Early trauma, resulting in focal areas of cartilage damage with injury to the underlying subchondral bone (osteochondral damage) often progresses to arthritis. These so called osteochondral defects (OCDs) can arise from ... -
Chitin-derived STING Activators as Adjuvants and Therapeutics
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)A significant challenge in the advancement of vaccine research is a lack of adjuvants that can safely drive potent cellular immunity against intracellular pathogens and cancer, a problem only exacerbated by our limited ... -
CRISPR Gene Editing Approaches in the Study of Allergy and Infertility
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019) -
Inhibitor of Apoptosis Proteins as Targets for the Treatment of Malignant Rhabdoid Tumours
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)Malignant rhabdoid tumor (MRT) is a rare paediatric cancer which unfortunately is highly refractive to treatment. Retrospective reviews commonly place the survival rate at approximately 30-35 %. Thus, there is an urgent ... -
Investigating the role of cell wall-anchored proteins during Staphylococcus aureus skin infection and as vaccine antigens
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Staphylococcus aureus has become increasingly resistant to antibiotics and community acquired methicillin resistant S. aureus (CA-MRSA) skin and soft tissue infections (SSTIs) are occurring with increasing frequency in ... -
NK cell function and metabolism in human cancer
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Natural Killer (NK) cells are important anti-cancer innate immune cells. They are essential for cancer immunosurveillance and their activity is associated with better outcome in cancer patients. Some of their key ... -
PATHOGENIC PROTEIN AGGREGATION IN VIVO AND IN VITRO
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Neurodegenerative disorders (ND) such as Alzheimer?s disease (AD), Parkinson?s disease (PD) and amyotrophic lateral sclerosis (ALS) are one of the leading causes of death and disabilities worldwide. While their aetiologies ... -
Regulation of bovine beta-defensin expression
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2017)Beta-defensins are a class of host defence peptides with antibacterial, antiviral and immunomodulatory roles. The bovine genome contains up to 57 putative beta-defensin genes in four syntenic clusters on different chromosomes. ... -
The roles of cytoplasmic aspartate aminotransferase in trypanosoma brucei
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2017)