Browsing Biochemistry (Theses and Dissertations) by Sponsor "SFI stipend"
Now showing items 1-4 of 4
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Investigating the role of specific inflammasome components during inflammatory disease
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)Inflammasomes are multi-protein complexes that act as intracellular innate immune receptors. The first inflammasome was initially defined by Martinon et al in 2002 and 16 years on, this increasingly explored area has led ... -
Re-evaluating the Role of SARM1 as a Transcriptional Regulator Using Improved Genome-Edited Mouse Models
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)SARM1 is an ancient and highly conserved protein, initially described as having functions in innate immunity. In the last decade, our understanding of SARM1 structure and function expanded rapidly. The majority of research ... -
Size regulates particulate adjuvant induced IL-10 and IL-12p70 production
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Until recently, vaccines were largely comprised of whole cell killed and attenuated pathogens. However, over recent decades, there has been a shift towards subunit vaccine development, using purified antigens which although ... -
Structural studies of myxoma virus antagonists of innate immunity
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)Viral evasion of the host immune system is achieved via antagonism of antiviral signalling pathways by the expression of immunomodulating proteins. Vaccinia virus protein C7 and its homologues function as determinants ...
