Browsing Biochemistry (Theses and Dissertations) by Sponsor "European Research Council (ERC)"
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The Immunomodulatory Metabolite Itaconate Regulates NLRP3 Inflammasome Activation and Type I Interferon Signalling
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)The NLRP3 inflammasome is a multi-protein complex which activates caspase-1 for the cleavage and release of mature IL-1β and IL-18. Caspase-1 also cleaves gasdermin D, driving a process called pyroptosis. Results from ... -
Single cell analysis of iNKT cell heterogeneity, phenotype, and function
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Innate T cells, including CD1d-restricted invariant natural killer T (iNKT) cells, are characterized by their rapid activation in response to non-peptide antigens, such as lipids. While the transcriptional profiles of ...