Browsing Biochemistry (Theses and Dissertations) by Author "Hooftman, Alexander"
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The Immunomodulatory Metabolite Itaconate Regulates NLRP3 Inflammasome Activation and Type I Interferon Signalling
Hooftman, Alexander (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)The NLRP3 inflammasome is a multi-protein complex which activates caspase-1 for the cleavage and release of mature IL-1β and IL-18. Caspase-1 also cleaves gasdermin D, driving a process called pyroptosis. Results from ...