Browsing Physiology (Scholarly Publications) by Title
Now showing items 115-134 of 136
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Rapid and differential regulation of AMPA and kainite receptors at hippocampal mossy fibre synapses by PICK1 and GRIP
(2003)We identified four PDZ domain-containing proteins, syntenin, PICK1, GRIP, and PSD95, as interactors with the kainate receptor (KAR) subunits GluR52b, GluR52c, and GluR6. Of these, we show that both GRIP and PICK1 interactions ... -
Regulation of synaptic strength & AMPA receptor subunit composition by PICK1
(2004)PICK1 (protein interacting with C kinase-1) regulates the surface expression of the AMPA receptor (AMPAR) GluR2 subunit, however,the functional consequences of this interaction are not well understood. Previous work has ... -
The relationship of medical, demographic and psychosocial factors to direct and indirect health utility instruments in rheumatoid arthritis.
(2006)Cost-effectiveness analysis (CEA) is essential for the comparison of treatments for rheumatoid arthritis (RA). CEA centres on accurate measurement of health utility (HU) preferences. Direct measures of HU in RA patients ... -
Removal of Synaptic Ca2+-Permeable AMPA Receptors during Sleep.
(2011)here is accumulating evidence that sleep contributes to memory formation and learning, but the underlying cellular mechanisms are incompletely understood. To investigate the impact of sleep on excitatory synaptic transmission, ... -
Respiratory infection promotes T cell infiltration and Aβ deposition in APP/PS1 mice.
(2014)Alzheimer?s disease (AD) is a progressive neurodegenerative disease characterized by deposits of amyloid-? and neurofibrillary tangles. It has been suggested that inflammatory changes are associated with disease; however, ... -
Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus.
(The American Society for Biochemistry and Molecular Biology, 2005)It is well documented that long term potentiation (LTP) is impaired in the hippocampus of the aged animal. Among the changes that contribute to this impairment is an increase in hippocampal concentration of the pro-inflammatory ... -
Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP.
(2012)Neuroinflammation is a significant and consistent feature of many neurodegenerative disorders, including Alzheimer?s disease (AD) and Parkinson?s disease (PD). The greatest risk factor for neurodegenerative disorders is ... -
Rosiglitazone improves spatial memory and decreases insoluble A?(1-42) in APP/PS1 mice.
(2012)Identifying potential novel treatments for patients with Alzheimer?s disease (AD) is a major challenge and drugs used for other indications, particularly if they have anti- inflammatory properties, are particularly ... -
SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis.
(2008)Peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator-1alpha (PGC-1alpha) is a highly regulated transcriptional coactivator that coordinates energy metabolism in mammals. Misregulation of PGC-1alpha has ... -
The Schizophrenic Faces of PICK1
(2006)Schizophrenia is a grave psychiatric disorder with psychotic symptoms and an enigmatic etiology. Family studies have strongly indicated that genetic risk factors have a role in this disease. Recent findings, together ... -
SIGIRR modulates the inflammatory response in the brain
(Elsevier, 2010)One of the more recently described members of the interleukin-1 (IL-1) receptor family, single-Ig-Interleukin-1 related receptor (SIGIRR), has been identified as a negative regulator of inflammation in several tissues. ... -
Sleep Spindles as Facilitators of Memory Formation and Learning
(2016)Over the past decades important progress has been made in understanding the mechanisms of sleep spindle generation. At the same time a physiological role of sleep spindles is starting to be revealed. Behavioural studies ... -
Small-Molecule Inhibitors at the PSD-95/nNOS Interface have Antidepressant-Like Properties in Mice.
(2013)Previous studies have demonstrated that nitric oxide (NO) synthase inhibitors are as efficacious as tricyclic antidepressants in preclinical antidepressant screening procedures and in attenuating behavioural deficits ... -
Spatial representation of predictive motor learning
(American Physiological Society, 2003)A key feature of skilled motor behavior is the ability of the CNS to predict the consequences of its actions. Such prediction occurs when one hand pulls on an object held in the other hand; the restraining hand generates ... -
Sphingosine 1-phosphate receptors regulate TLR4-induced CXCL5 release from astrocytes and microglia
(2018)Sphingosine 1-phosphate receptors (S1PR) are G protein-coupled and compose a family with five subtypes, S1P1R–S1P5R. The drug Gilenya ® (Novartis, Basel, Switzerland) (Fingolimod; FTY720) targets S1PRs and was the first ... -
System for performance measures of predictive grip in a dynamic haptic environment
(2004)Virtual environments provide a powerful means of experimentally examining object manipulation. In object manipulation a key issue is the coor- dination of grip force used to stabilize the object in the presence of load ... -
Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations
(2014)Fingolimod (FTY720) is an oral therapy for relapsing remitting multiple sclerosis (MS) and targets sphingosine 1-phosphate receptors (S1PRs). FTY720 also rescues animals from experimental autoimmune encephalomyelitis (EAE), ... -
Tissue Engineering of Cartilage; Can Cannabinoids Help?
(2010)This review discusses the role of the cannabinoid system in cartilage tissue and endeavors to establish if targeting the cannabinoid system has potential in mesenchymal stem cell based tissue-engineered cartilage repair ... -
Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-β
(2013)The family of toll-like receptors (TLR) plays a major role in innate immunity due to their pathogen-recognition abilities. TLR3 is a sensor for double-stranded RNA, and regulates host-defense responses to several viruses, ...