Respiratory infection promotes T cell infiltration and Aβ deposition in APP/PS1 mice.
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2014Access:
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McManus R, Mills, KHG, Lynch MA, Respiratory infection promotes T cell infiltration and Aβ deposition in APP/PS1 mice., Neurobiol Aging, 35, 1, 2014, 109 121Download Item:
McManus et al 2013.pdf (Published (author's copy) - Peer Reviewed) 1.205Mb
Abstract:
Alzheimer?s disease (AD) is a progressive neurodegenerative disease characterized by deposits
of amyloid-? and neurofibrillary tangles. It has been suggested that inflammatory changes are
associated with disease; however, it has not been established if these are a consequence of
ongoing neurodegeneration or whether inflammation itself contributes to disease pathogenesis.
Recent studies suggest that exposure to infection can accelerate cognitive decline in AD
patients, and pathogens have been detected in the AD brain. However, the influence of
infection on neuroinflammation and pathology remains poorly understood. In this study, we
examined the effect of a peripheral infection on AD pathology in APP/PS1 mice. We found
that, 8 weeks after infection with the Gram negative respiratory pathogen Bordetella pertussis,
there was significant infiltration of IFN?- and IL-17-producing T cells and NKT cells in older
APP/PS1 mice. This was accompanied by increased glial activation and amyloid ? deposition.
The data suggest that infection is a critical factor in the progression of AD, emphasising the
importance of early diagnosis and treatment of infections in elderly individuals.
Author's Homepage:
http://people.tcd.ie/lynchmahttp://people.tcd.ie/millsk
http://people.tcd.ie/rmcmanus
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Neurobiol Aging35
1
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Immunology, Inflammation & Infection , NeuroscienceDOI:
http://dx.doi.org/10.1016/j.neurobiolaging.2013.07.025Licences: