Browsing Physiology (Scholarly Publications) by Title
Now showing items 89-108 of 136
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Modest Amyloid Deposition is Associated with Iron Dysregulation, Microglial Activation, and Oxidative Stress.
(2012)There is a well-established literature indicating a relationship between iron in brain tissue and Alzheimer's disease (AD). More recently, it has become clear that AD is associated with neuroinflammatory and oxidative ... -
Modulation of intestinal microbiota by the probiotic VSL#3 resets brain gene expression and ameliorates the age-related deficit in LTP.
(2014)The intestinal microbiota is increasingly recognized as a complex signaling network that impacts on many systems beyond the enteric system modulating, among others, cognitive functions including learning, memory and ... -
Monocytes exposed to plasma from patients with Alzheimer's disease undergo metabolic reprogramming.
(2019)The search for a blood-based biomarker that identifies Alzheimer’s disease (AD) and can replace current invasive and expensive diagnostic tests, continues. The most extensively-examined peripheral marker is β-amyloid (Aβ) ... -
A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus
(Elsevier, 2011)Neuroglial activation is a typical hallmark of ageing within the hippocampus, and correlates with age-related cognitive deficits. We have used quantitative immunohistochemistry and morphometric analyses to investigate ... -
The neural cell adhesion molecule-derived peptide, FGL, attenuates lipopolysaccharide-induced changes in glia in a CD200-dependent manner.
(2013)Fibroblast growth loop (FGL) is a neural cell adhesion molecule (NCAM)-mimetic peptide that mimics the interaction of NCAM with fibroblast growth factor receptor (FGFR). FGL increases neurite outgrowth and promotes ... -
Neuroinflammatory changes increase the impact of stressors on neuronal function.
(2009)In the last few years, several research groups have reported that neuroinflammation is one feature common to several neurodegenerative diseases and that similar, although perhaps less profound, neuroinflammatory changes ... -
Neuroinflammatory changes negatively impact on LTP: a focus on IL-1β
(2015)In recent years it has become clear that neuroinflammatory changes develop in the brain with age and that similar, though more profound changes, occur in neurodegenerative conditions and in animal models of neurodegeneration. ... -
Neuropathology in Mice Expressing Mouse Alpha-Synuclein
(PLoS, 2011)?-Synuclein (?SN) in human is tightly linked both neuropathologically and genetically to Parkinson's disease (PD) and related disorders. Disease-causing properties in vivo of the wildtype mouse ortholog (m?SN), which carries ... -
Neuroprotective actions of eicosapentaenoic acid on lipopolysaccharide-induced dysfunction in rat hippocampus
(Wiley & Sons, 2004)Eicosapentaenoic acid (EPA) protects hippocampus from age-related and irradiation-induced changes that lead to impairment in synaptic function; the evidence suggests that this is due to its anti-inflammatory effects, ... -
Neurostimulation techniques for the modulation of pain
(intech, 2018) -
The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1β-dependent manner in macrophages
(2019)Infammation and metabolism are intricately linked during infammatory diseases in which activation of the nucleotide-binding domain–like receptors Family Pyrin Domain Containing 3 (NLRP3) infammasome, an innate immune ... -
Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex
(2010)Evidence indicates that noradrenaline elicits anti-inflammatory actions in the central nervous system (CNS), and plays a neuroprotective role where inflammatory events contribute to pathology. Here we examined the ability ... -
Noradrenaline reuptake inhibitors limit neuroinflammation in rat cortex following a systemic inflammatory challenge: implications for depression and neurodegeneration.
(Cambridge University Press, 2009)Evidence suggests that noradrenaline has a tonic anti-inflammatory action in the central nervous system (CNS) via its ability to suppress microglial and astrocytic activation, and inhibit production of inflammatory mediators. ... -
Pathway specific modulation of S1P1 receptor signalling in rat and human astrocytes.
(2013)BACKGROUND AND PURPOSE: The sphingosine 1-phosphate receptor subtype 1 (S1P1R) is modulated by phosphorylated FTY720 (pFTY720), which causes S1P1R internalization preventing lymphocyte migration thus limiting autoimmune ... -
The PDZ Domain of PICK1 Differentially Accepts Protein Kinase C-α and GluR2 as Interacting Ligands
(2004)The C terminus (ct) of protein kinase C-α (PKCα) has a type I PDZ binding motif, whereas GluR2 has a type II PDZ binding motif. Both motifs are recognized by the PDZ domain of protein interacting with protein kinase C ... -
PDZ Proteins interacting with c-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses
(2000)We investigated the role of PDZ proteins (GRIP, ABP, and PICK1) interacting with the C-terminal GluR2 by infusing a ct-GluR2 peptide (“pep2-SVKI”) into CA1 pyramidal neurons in hippocampal slices using whole-cell recordings. ... -
The PDZ Proteins PICK1, GRIP and Syntenin bind multiple glutamate receptor subtypes
(2002)Using sequence homology searches, yeast two-hybrid assays and glutathione S-transferase (GST)-pull-down approaches we have identified a series of glutamate receptor subunits that interact differentially with the PDZ proteins ... -
Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor
(2012)The endocannabinoid system is an important regulator of the nervous, neuroendocrine and immune systems, thus representing a novel therapeutic target for stress-related neuroinflammatory and psychiatric disorders. However, ... -
Physiological changes following a 12 week gym based stair-climbing, elliptical trainer and treadmill running program in females
(Minerva Medica, 2004)Despite the growing popularity of the elliptical trainer aerobic exercise modality the physiological changes induced following a training program using elliptical trainers remains unknown. Donne investigates the metabolic ...