Browsing Pharmacology & Therapeutics (Theses and Dissertations) by Title
Now showing items 13-32 of 46
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Endogenous acetylcholine modulates synaptic plasticity in the hippocampus in vivo
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)Long-term potentiation (LTP) provides a model for the synaptic mechanisms underlying learning and memory. Acetylcholine (ACh) is an important excitatory transmitter in the hippocampus, and cholinergic activity is essential ... -
Genetic polymorphisms and arterial stiffness
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)Arterial stiffness exerts a major influence on cardiac afterload and coronary perfusion. Indices of arterial stiffness have therefore been proposed as surrogate markers of cardiovascular risk and as potential therapeutic ... -
Health economics in the Irish healthcare setting
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)Economic analysis plays a key role in deciding which healthcare interventions should be made available in collectively funded healthcare systems. The aim of this thesis is to examine the application of health economics in ... -
Health technology assessment in the Irish healthcare setting : application to oral anticoagulants
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2012)The objective of this thesis was to examine the application of economic evaluation within the Irish healthcare setting. In so doing, the author sought to develop skills in indirect comparison, economic modelling, value of ... -
Health Technology Assessment of CD19 CAR T-Cell Therapies in the Irish Healthcare Setting.
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2022)The aim of this research was to undertake health technology assessments of CD19 CAR T-cell therapies, tisagenlecleucel and axicabtagene ciloleucel. A bespoke cost-utility model was developed to examine the cost effectiveness ... -
Hippocampal long-term depression in anaesthetised adult rats: Involvement of glutamate and acetylcholine receptors
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2017)Abstract: Hippocampal long-term depression in anaesthetised adult rats: Involvement of glutamate and acetylcholine receptors Kenneth J. O?Riordan Department of Pharmacology and Therapeutics School of Medicine, University ... -
Identifying early indicators of Emotional and Behavioural Difficulties in Irish children and testing the feasibility of an online parenting intervention for improving child mental health
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2019)Background: Emotional and behavioural difficulties (EBDs) are the most common reason for referral of children and adolescents to mental health services. It is important, therefore, to assess the overall prevalence of EBD ... -
The innate immunomodulatory effects of Aquamin in the context of the metabolic syndrome
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2023)Metabolic disease is a combination of conditions that manifest together, elevating the risk for cardiovascular disease, type 2 diabetes and stroke. Inflammation is a major contributor in the pathophysiology of metabolic ... -
Left ventricular diastolic function in early hypertension
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)This thesis presents the development of clinical applications of the relatively new ultrasound modality, TDI in conjunction with the earlier more established modalities of echocardiography. The contents of this thesis ... -
Local modulation of pulmonary vascular function
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2000)The aim of the present study was to investigate the role of endothelial smooth muscle interaction in the local modulation of pulmonary vascular function. The main part of the work was carried out in isolated rings of porcine ... -
Metformin, aspirin, and colorectal cancer outcomes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2013)Colorectal cancer is the second most incident cancer in men and women in Ireland and is the third greatest cause of cancer death. Metformin and aspirin, two drugs which are commonly used in type 2 diabetes and cardiovascular ... -
Modelling compliance with antihypertensives and statins in Ireland, using a national prescription claims database
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)Hypertension and high cholesterol, especially in the middle-aged and elderly, are fairly common, and pharmacological therapy is often required to control them. In spite of substantial knowledge of the consequences of ... -
Multiple sclerosis in Ireland : costs, health-related quality of life and cost effectiveness of disease-modifying therapies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2014)This study aimed to evaluate the economic and health-related quality of life (HRQoL) burden of multiple sclerosis (MS) in Ireland, and to develop a framework for assessing the cost effectiveness of disease-modifying therapies ... -
Neurotransmitter interactions in the control of spatial memory and exploratory activity in the rat
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)The role of the central cholinergic system in learning and memory is well established, with many investigations reporting that central cholinergic hypofunction is correlated with impaired performance on various behavioural ... -
Nuclear receptor activation by antiretroviral drugs used in the treatment of HIV disease with implications for xenobiotic and endobiotic processes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2012)Genotyping: DNA was isolated from whole blood of 1013 HIV-patients and genotyped commercially for 37 single nucleotide polymorphisms (SNPs) and one 3-basepair insertion in genes of relevance for drug interactions: NR1I2 ... -
Pharmaceutical pricing and reimbursement : an Irish perspective
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)There has been a five-fold increase in state expenditure on medicines under the Community Drug Schemes in Ireland over the last decade (1994 to 2004). As a result of this marked increase in pharmaceutical expenditure, the ... -
Pharmacoeconomics of Statin Therapy in Ireland
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)Cardiovascular disease is the leading cause of death in most industrialised countries, including Ireland. Cholesterol lowering by pharmacological intervention prevents atherosclerotic plaque progression and has been shown ... -
Pharmacoepidemiological studies of breast and colorectal cancer: The association between statins and cancer outcomes
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2019)Breast and colorectal cancer are two of the most commonly diagnosed cancers in Ireland and worldwide, and a significant cause of cancer deaths. Statins, which are drugs that are commonly used in the prevention of ... -
Pharmacoepidemiology of diabetes mellitus in a national population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2010)Diabetes is associated with significant morbidity and mortality from microvascular and macrovascular complications. It is projected that the prevalence of diabetes will increase worldwide especially in the elderly population ... -
The Pharmacokinetic Interaction between Ivacaftor and Ritonavir
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2019)Ivacaftor is the first small molecule for the treatment of cystic fibrosis (CF) that directly targets the inherited defect in the cystic fibrosis transmembrane conductance regulator (CFTR). In phase III clinical trials ...
