A comparative genomics analysis of the vertebrate immune system : genes, pathways and evolution
Citation:
Paul Cormican, 'A comparative genomics analysis of the vertebrate immune system : genes, pathways and evolution', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009, pp 174Download Item:
Abstract:
All species possess a selection-honed collection of genes whose products
function in unison to form a barricade to invading pathogens. The exponential
increase in publicly available sequence data has allowed the application of
bioinformatics approaches to explore the conservation and variation of immune
genes when compared between species. Antimicrobial peptides (AMPs) are
important effector molecules of the immune response. Intra and inter genomic
analysis indicates that, although AMPs are evolutionarily conserved across
species, subgroups of gene lineages exist that are specific to certain species.
We applied a Hidden Markov Model (HMM) profile search method to
identification of the β-defensin family of AMPs in cattle and characterised the
most greatly expanded gene family of any mammal thus far examined.
Author: Cormican, Paul
Advisor:
O'Farrelly, ClionaQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Biochemistry and ImmunologyNote:
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