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  Characterisation of Membrane Glycoproteins that are Essential for Flagellar Attachment in the Bloodstream Form of Trypanosoma brucei 

  MCATEER, LOUISE (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)

  The African trypanosome, Trypanosoma brucei, is a unicellular parasitic protist that causes a severe disease, trypanosomiasis, in humans and livestock in sub-Saharan Africa. The trypanosome has a single flagellum that ...
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  Diverse Immunoregulatory Roles of Oxysterols - The Oxidized Cholesterol Metabolites 

  Finlay, David (2020)

  Intermediates of both cholesterol synthesis and cholesterol metabolism can have diverse roles in the control of cellular processes that go beyond the control of cholesterol homeostasis. For example, oxidized forms of ...
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  Metabolic but not transcriptional regulation by PKM2 is important for Natural Killer cell responses 

  Finlay, David (2020)

  Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating changes in signal transduction pathways and cellular metabolism is essential for effective NK cells responses. The ...
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  Characterizing caspase-1 involvement during esophageal disease progression. 

  Creagh, Emma; O'Sullivan, Jacintha (2020)

  Barrett’s esophagus (BE) is an inflammatory condition and a neoplastic precursor to esophageal adenocarcinoma (EAC). Inflammasome signaling, which contributes to acute and chronic inflammation, results in caspase-1 activation ...
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  Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation 

  Zisterer, Daniela (2020)

  Histone deacetylase inhibitors (HDACi) have emerged as promising therapeutics for the treatment of neurodegeneration, cancer, and rare disorders. Herein, we report the development of a series of spiroindoline-based HDAC6 ...

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