RSS 1.0Biochemistry
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Biochemistry (Theses and Dissertations)
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In silico analysis of the human milk oligosaccharide glycome reveals key enzymes of their biosynthesis.
(2022)Human milk oligosaccharides (HMOs) form the third most abundant component of human milk and are known to convey several benefits to the neonate, including protection from viral and bacterial pathogens, training of the ... -
Adrenergic, Circadian, and Dietary Regulation of Interleukin-17A Expression by Adipose Gamma-Delta T Cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Adipose tissue is home to a unique population of IL-17A expressing Gamma-Delta T cells (Gamma-Delta17 T cells), which are necessary for maintaining body temperature during cold environmental temperatures. However, the ... -
Pre-clinical development of NOX2/ROS blood-based biomarker of TBI
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)There is an urgent need to develop predictive biomarkers for traumatic brain injury (TBI) to aid clinical diagnosis and treatment of head injury patients. NADPH oxidase 2 (NOX2) activity and oxidized biomarkers are being ... -
Characterisation of Innate Immune and Metabolic Roles of SARM1 in Mouse Macrophages.
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Engagement of the NLRP3 inflammasome in response to injury or infection results in the activation of the pro-inflammatory protease, caspase-1. Cleavage of the caspase-1 substrate, gasdermin D (GSDMD), leads to the GSDMD ... -
Single cell analysis of iNKT cell heterogeneity, phenotype, and function
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Innate T cells, including CD1d-restricted invariant natural killer T (iNKT) cells, are characterized by their rapid activation in response to non-peptide antigens, such as lipids. While the transcriptional profiles of ...
