Recent Submissions

  • NLRP1 drives inflammasome responses in the human respiratory epithelium 

    Lam, Nathaniel Laurence (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)
    The airway epithelium is now considered crucial to the orchestration of respiratory inflammatory responses and tissue remodelling. It functions as the first line of defence against inhaled concomitants and coordinates the ...
  • Adrenergic, Circadian, and Dietary Regulation of Interleukin-17A Expression by Adipose Gamma-Delta T Cells 

    Douglas, Aaron Keith (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
    Adipose tissue is home to a unique population of IL-17A expressing Gamma-Delta T cells (Gamma-Delta17 T cells), which are necessary for maintaining body temperature during cold environmental temperatures. However, the ...
  • Pre-clinical development of NOX2/ROS blood-based biomarker of TBI 

    Emediato, Isabella Dias (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
    There is an urgent need to develop predictive biomarkers for traumatic brain injury (TBI) to aid clinical diagnosis and treatment of head injury patients. NADPH oxidase 2 (NOX2) activity and oxidized biomarkers are being ...
  • Characterisation of Innate Immune and Metabolic Roles of SARM1 in Mouse Macrophages. 

    Shanahan, Katharine Ann (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
    Engagement of the NLRP3 inflammasome in response to injury or infection results in the activation of the pro-inflammatory protease, caspase-1. Cleavage of the caspase-1 substrate, gasdermin D (GSDMD), leads to the GSDMD ...
  • Single cell analysis of iNKT cell heterogeneity, phenotype, and function 

    Kane, Harry (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
    Innate T cells, including CD1d-restricted invariant natural killer T (iNKT) cells, are characterized by their rapid activation in response to non-peptide antigens, such as lipids. While the transcriptional profiles of ...

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