RSS 1.0Trinity College Dublin Theses & Dissertations
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The altered immune microenvironment of human liver in metastatic disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Globally, metastatic colon cancer is a significant disease with poor outcomes. Liver metastases are the leading cause of death and, despite maximal medical management, recurrent metastases are seen in up to 70% of patients ... -
The value of ex situ collections for global biodiversity conservation in the wild
(Trinity College Dublin. School of Natural Sciences. Discipline of Zoology, 2021)Despite the best efforts of conservation practitioners global biodiversity is continuing to decline. The role of zoos and aquariums in conserving global biodiversity ex situ has become increasingly important as more species ... -
Development of a performance framework to support the innovation process
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)Performance frameworks (PFs) for measuring the innovation process are critical for both research and practice. However, existing PFs neglect performance indicators (PIs) and dimensions relevant to companies' current ... -
Investigations into Metal-Binding Groups to Probe the DNA Repair Nuclease SNM1A
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2021)SNM1A is a nuclease that is implicated in DNA interstrand crosslink repair and as such is of importance to regular cellular function. However, little is known about its roles, regulation, interaction partners or posttranslational ... -
On the Genotype and Phenotype of inherited retinal degenerations in an irish popultion
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Aim: To elucidate the molecular diagnosis and perform deep phenotyping on patients with inherited retinal degenerations (IRDs) Methods: Patients were identified through self-referral or referral by an ophthalmologist ...
