Trinity College Dublin Theses & Dissertations
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Investigating the therapeutic utility of Olaparib in Metachromatic Leukodystrophy and Krabbe Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2024)Leukodystrophies encompass a diverse group of genetically-based disorders that impact the development and preservation of myelin in the central nervous system's white matter. These conditions, affecting approximately 1 in ... -
Investigating a role for SARM1 in retinal degeneration
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Retinal degenerative diseases, such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD), represent a leading cause of incurable blindness worldwide. RP is a genetically inherited retinal degeneration ... -
Tumours have a sex: impact on the response of bladder cancer and lung adenocarcinoma to therapy
(Trinity College Dublin. School of Medicine. Discipline of Radiation Therapy, 2024)Background: The 23rd pair of chromosomes in humans is responsible for sex determination, in which humans are categorised as female (XX chromosomes) or male (XY chromosomes). While phenotypically, male and females are ... -
Characterisation of Microbial Biomat Development in Soil Treatment Units Receiving Domestic Effluent
(Trinity College Dublin. School of Engineering. Disc of Civil Structural & Environmental Eng, 2024)Soil treatment units are an essential part on on-site wastewater treatment system. In Ireland there are approximately 500,000 on-site wastewater treatment systems with 87% configured as a septic tank followed by a soil ... -
Parent-Infant Sleep as Co-Occupation: A Meta-Ethnography of Parent Experiences and Perspectives
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2024)Sleep is a key component of health and wellbeing for both adults and infants and has implications for daytime functioning and quality of life. Infants' sleep patterns in the first two years involve unpredictable, short ...