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  • A comparative genomics analysis of the vertebrate immune system : genes, pathways and evolution 

    Cormican, Paul (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)
    All species possess a selection-honed collection of genes whose products function in unison to form a barricade to invading pathogens. The exponential increase in publicly available sequence data has allowed the application ...
  • A role for eIF4A1 in IL-10 induction by LPS 

    Alam, M. Mustafa (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)
    microRNAs are a family of short non-coding RNAs that act as fine tuners of gene expression by controlling mRNAs. They have been implicated in numerous diseases including inflammatory diseases. A number of studies have ...
  • A role for microRNA-21 in the regulation of gastrointestinal health and disease 

    Johnston, Daniel (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2017)
    The gastrointestinal (GI) tract is a crucial site of innate and adaptive immune regulation, balancing tolerance of beneficial commensal microorganisms and reaction to invading pathgens. Pattern recognition receptors (PRRs), ...
  • A structural study of ALgE, transporter of alginate from Pseudomonas aeruginosa PAOI 

    Tan, Jingquan (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
    Pseudomonas aeruginosa is an opportunistic human pathogen that causes serious diseases in humans with immune system deficiencies, such as cystic fibrosis, wound infections, urinary tract infections, and blood stream ...
  • A study of the glycosylphosphatidylinositol phospholipase C in Trypanosoma brucei 

    O'Byrne, Robert (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
    Trypanosoma brucei represents a clade of flagellated parasites that cause human and animal trypanosomiases in sub-Saharan Africa. The glycosylphosphatidylinositol phospholipase C (GPI-PLC) is an endogenous enzyme that has ...
  • Activation and function of mucosal gamma delta T cells 

    Misiak, Alicja (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
    γδ T cells are innate-like lymphocytes characterised by rapid activation following infection or tissue injury. They are enriched in the skin and epitheliae of various organs, where breach of the barrier is likely to occur. ...
  • An integrated approach to oral vaccination against enteric pathogens 

    Davitt, Christopher (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)
    While the majority of human pathogens infect the body through mucosal sites, most licenced vaccines are injectable. In fact the only mucosal vaccine that is widely used for infant and childhood vaccination programs is the ...
  • An investigation into the role of TLR4 interactor with leucine rich repeats (TRIL) in Toll-like receptor responses in brain 

    Wochal, Paulina (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
    TLR4 interactor with leucine rich repeats (TRIL) was originally described as a protein required for Toll-like receptor 4 (TLR4) signalling. This thesis provides new insights into the function of TRIL within TLR signalling ...
  • An investigation into the role of TMED1 in IL-33/ST2L singalling pathway 

    Connolly, Dympna (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)
    This thesis set out to characterise the GOLD domain containing protein, TMED1 which had been shown to associate with ST2L, the receptor for the cytokine IL-33 and to investigate its relationship with ST2L.
  • An investigation of the physiological and pathological role of uncoupling proteins 

    Manzke, Lars (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)
    Uncoupling proteins (UCPs) are found in numerous different tissues and have been associated with many physiological and pathological conditions. After decades of research on uncoupling proteins, there is still only a modest ...
  • Analysis of mitochondrial proteomes and supercomplex structures in brain tissue 

    Brady, Laura (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
    Mitochondria play a complex multifactorial role in the control of cell bioenergetics. A primary function of mitochondria is the production of adenosine 5'-triphosphate (ATP) by the process of oxidative phosphorylation that ...
  • Characterisation of T cell responses during Staphylococcus aureus infection 

    Murphy, Alison (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)
    The development of anti-S. aureus vaccines has consistently failed in clinical trials, likely due to inefficient induction of cellular immunity. A comprehensive understanding of the discrete T cell subsets critical for ...
  • Chitosan based adjuvants promote proinflammatory Th1 and Th17 responses 

    Mori, Andres (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)
    Particulate vaccine adjuvants, including alum and biodegradable polymer microparticles, are strong activators of antigen-specific humoral immunity. These particulates enhance NLRP3 inflammasome activation, but they are ...
  • Delineating molecular mechanisms of inflammation-induced delirium using a novel mouse model 

    Skelly, Donal (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)
    Delirium is a syndrome of acute and transient confusion with disruption of attention and cognition; it is a common but underdiagnosed neuropsychiatric condition, which is predictive of increased fimctional decline, dementia ...
  • Dendritic cell mediated mucosal cross talk 

    Ruane, Darren (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
    Developing efficacious vaccines against enteric diseases is a global challenge and priority. The rational design of such vaccines requires that novel pathways of cellular recruitment to the gastrointestinal (GI) tract be ...
  • Distinct local and systemic innate immune gene expression in response to Staphylococcus aureus-induced subclinical mastitis 

    Whelehan, Cormac (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)
    Both local and systemic innate immune activity has a critical role in maintaining immunological homeostasis in the mammary gland. Dysregulation of the homeostatic process leads to increased infection and related pathology, ...
  • Evaluation of the anti-cancer effects of novel pyrrolo-1, 5-benzoxazepines in neuroblastoma 

    Lennon, Jennifer (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
    Neuroblastoma, a malignancy of neuroectodermal origin, accounts for 15% of childhood cancer deaths. Despite both advances in understanding the biology of the cancer and aggressive treatment strategies, it continues to be ...
  • Exploring an immune function for murine SARM 

    Gürtler, Claudia (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)
    Innate immune cells, such as tissue-residing macrophages and dendritic cells (DCs) play a key role in initiating an immune response following the detection of invading pathogens via germline-encoded pattern-recognition ...
  • Immune modulation by the helminth parasite Fasciola hepatica 

    Finlay, Conor Michael (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
    The incidence of allergic and autoimmune disease In the developed world has Increased dramatically In the past century. This has coincided with a reduction In the Incidence of infectious disease. The hygiene hypothesis ...
  • Immunomodulatory activity of products from the helminth parasite Fasciola hepatica 

    Stefanska, Anna M. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
    Helminths have evolved strategies to evade host immune responses and these have been shown to be associated with simultaneous subversion of immune responses towards bystander antigens. This phenomenon forms the basis of ...